Mechanisms of release and renal action of atrial natriuretic factor.

Mechanisms of release and renal action of atrial natriuretic factor. Research Abstract Details 

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Mechanisms of release and renal action of atrial natriuretic factor. Abstract Text:

H Sonnenberg,

In addition to the well-documented stretch-induced secretion of atrial natriuretic factor (ANF), we have shown that addition of agonists such as vasopressin or angiotensin, added to incubation medium with freshly excised rat atria, caused marked release of the hormone in vitro. Others have had difficulty in reproducing these results. In experiments designed to address this problem we found that removal of the atrial endothelium was necessary to demonstrate agonist-induced release of ANF. The results suggest that the endothelial lining of atrial tissue may limit access of the agonists to the myocytes, and thereby play a modulating role in receptor-stimulated secretion of the hormone. The renal mechanism of action of ANF includes inhibition of Na transport in the medullary collecting duct (MCD). Recent in vitro studies have suggested that this inhibition occurs via blockade of amiloride-sensitive Na channels. However, ANF-induced reduction of MCD transport in vivo is much greater than that obtainable with amiloride. Although, by luminal administration of ANF in vivo, we were able to confirm an amiloride-like action of the hormone at this site, we could not thereby mimic the effects of systemic ANF on MCD Na reabsorption. The results thus indicate that a peritubular effect is an important determinant of ANF natriuresis.

Mechanisms of release and renal action of atrial natriuretic factor. Publishing Authors By Initials

H Sonnenberg,

For similar urogenital system: urinary tract: kidney research abstracts see: urogenital system: urinary tract: kidney research

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Mechanisms of release and renal action of atrial natriuretic factor. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta physiologica Scandinavica. Supplementum

VOLUME: 591

Page Numbers: 80-7

Journal Abbreviation:

ISSN: 0302-2994

DAY: 20

MONTH: 02

YEAR: 1990

Mechanisms of release and renal action of atrial natriuretic factor. Information

Number of References: 29

LANGUAGE: eng

NlmUniqueID: 376307

Mechanisms of release and renal action of atrial natriuretic factor. Keywords Mesh Terms:

KEYWORDS: Kidney

MESH TERMS: physiology

Chemical & Substance for Abstract: Mechanisms of release and renal action of atrial natriuretic factor. Information

Substance Name: Atrial Natriuretic Factor

Registry Number: 85637-73-6

Grant and Affiliation Information for Mechanisms of release and renal action of atrial natriuretic factor.

AFFILIATION: Department of Physiology, University of Toronto, Canada.

Country: ENGLAND

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MEDLINETA: Acta Physiol Scand Suppl

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