Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy.

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Abstract Text:

Eduardo B Rodrigues,Carsten H Meyer,Stefan Mennel,Michel E Farah,

PURPOSE: Indocyanine green (ICG) dye was shown to improve the visualization of preretinal tissues during chromovitrectomy. However, controversy arose regarding the safety of intravitreal ICG application, because worse functional outcomes and a higher incidence of retinal pigment epithelium (RPE) changes and visual field defects were reported. The mechanisms of ICG-related toxicity and their relevance for chromovitrectomy are reviewed. METHODS: A literature search was performed from 1998 through 2005 for relevant information related to the mechanisms of intravitreal ICG toxicity. Animal and clinical data on intravitreal ICG-related toxicity were collected to clarify the mechanisms of the risk of intravitreal ICG injection. RESULTS: Over 80 controversial in vitro, ex vivo, and in vivo animal investigations as well as clinical reports on intravitreal ICG staining were found in the literature. The main postulated mechanisms of intravitreal ICG-related toxicity were as follows: biochemical direct injury to the ganglion cells/neuroretinal cells, RPE cells, and superficial retinal vessels; apoptosis and gene expression alterations to either RPE cells or neuroretinal cells; osmolarity effect of ICG solution on the vitreoretinal interface; light-induced injury; and mechanical cleavage effect to the internal limiting membrane/inner retina. Whereas the exact mechanism of intravitreal ICG-related damage remains yet to be determined, most animal experiments proposed that ICG dye has a dose-dependent toxic effect on retinal tissue. This hypothesis was supported by clinical data, because better functional outcomes were obtained when low dye concentrations and short incubation times were reported. CONCLUSIONS: Much evidence supports that ICG dye has a dose-dependent toxic effect on the retina. Therefore, the following recommendations to minimize toxic effects on the retina are proposed: dye injection in concentrations as low as possible; avoidance of repeated ICG injections onto bare retina; dye injection far from the macular hole to prevent direct dye contact with the RPE; short incubation time of ICG in the vitreous cavity to diminish the concentration in contact with the retinal tissue; and the light pipe kept far from the retina throughout the whole surgical procedure.

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Publishing Authors By Initials

EB Rodrigues,CH Meyer,S Mennel,ME Farah,

For similar vitreous body research abstracts see: vitreous body research

PUBMED ID PMID:

MEDLINE DATE:

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Journal Published:

PUBLICATION TYPE: Review

Journal: Retina (Philadelphia, Pa.)

VOLUME: 27

Page Numbers: 958-70

Journal Abbreviation: Retina (Philadelphia, Pa.)

ISSN: 0275-004X

DAY: 19

MONTH: Sep

YEAR: 2007

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Information

Number of References: 101

LANGUAGE: eng

NlmUniqueID: 8309919

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Keywords Mesh Terms:

KEYWORDS: Vitreous Body

MESH TERMS: surgery

Chemical & Substance for Abstract: Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy. Information

Substance Name: Indocyanine Green

Registry Number: 3599-32-4

Grant and Affiliation Information for Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy.

AFFILIATION: Retina Department, Hospital Regional Sao Jose, Instituto de Olhos Florianopolis, Centro Oftalmologico, Florianopolis, Brazil. edubrodriguess@yahoo.com.br

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Retina

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy Related Publications

• Assessment of Cellular Responses to Oxidative Stress using MCF-7 Breast Cancer Cells, Black Seed (N. Sativa L.) Extracts and H[2]O[2].
• Clinical presentation of sarcoidosis in a mixed population in the middle east.
• Combined photodynamic therapy and intravitreal triamcinolone injection for choroidal neovascularization in Best disease.
• Current neurosurgical trainees' perception of the European Working Time Directive and shift work.
• Experimental selective choriocapillaris photothrombosis using a modified indocyanine green formulation.
• Genetic variation in serotonin transporter alters resting brain function in healthy individuals.
• Influence of sodium load on sodium excretion.
• Lipodystrophy.
• Mechanisms of intravitreal toxicity of indocyanine green dye: implications for chromovitrectomy.
• Memories affect mood: evidence from covert experimental assignment to positive, neutral, and negative memory recall.
• Metrorrhagia after intravitreal injection of bevacizumab.
• Misleading promotion of drugs in Bangladesh: evidence from drug promotional brochures distributed to general practitioners by the pharmaceutical companies.
• RNAi silencing in mouse models of neurodegenerative diseases.
• Rationality is a better basis for ethics than repugnance.
• Socioeconomic gradients predict individual differences in neurocognitive abilities.
• Some factors influencing allergy in Lebanon.
• Structure of Xanthomonas axonopodis pv. citri YaeQ reveals a new compact protein fold built around a variation of the PD-(D/E)XK nuclease motif.
• The influence of sad mood on cognition.
• The role of cytokines in a Porphyromonas gingivalis-induced murine abscess model.
• The role of ventromedial prefrontal cortex in decision making: judgment under uncertainty or judgment per se?
• [A rare manifestation of hypothyroidism: intestinal obstruction. Report of 2 cases and review of the literature]
• [Creation of the St Joseph University Faculty of Medicine in Beirut: 125 years of Franco-Lebanese healthcare cooperation]
• [Intramural hematoma of the duodenum during closed injuries of the abdomen. Presentation of a case and review of the literature]
• [Laparoscopic adrenalectomy for pheochromocytoma. Case report and review of the literature]
• [Metastatic implants after laparoscopic cholecystectomy in unsuspected gallbladder cancer. A case report and review of the literature]
• [Parathyroid gland tumors]
• [Parathyroidectomy under local anesthesia. First two cases in Lebanon and review of the literature]
• [Post-traumatic strangulated diaphragmatic hernia.]
• [Spontaneous splenic rupture due to heparin. Report of a case and review of the literature]
• [The place of enucleation in the surgical management of hepatic hemangioma. Report of a case and review of the literature]