Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy.

Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Research Abstract Details 

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Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Abstract Text:

H Morimoto,K A Kelly,

The aim of this study was to determine whether insulin-induced relaxation of the proximal stomach after proximal gastric vagotomy is mediated by vagal release of antral gastrin. In six conscious, fasted dogs following proximal gastric vagotomy, the effects of intravenous insulin (1 U/kg) and intravenous gastrin (1 microg/kg) on proximal gastric motility, as measured by a gastric barostat, on plasma glucose, and on plasma gastrin, as measured by radioimmunoassay, were assessed 1 hour before and for 2 hours after injection. The effects of a cholecystokinin (CCK)-A receptor antagonist and a CCK-B receptor antagonist on insulin-induced or gastrin-induced relaxation of the proximal stomach and on plasma glucose and gastrin were also determined. Intravenous insulin decreased plasma glucose (before [mean +/- SD], 97 +/- 5 mg/dl vs. after, 45 +/- 3 mg/dl; P <0.05), increased plasma gastrin (before, 240 +/- 59 pg/ml vs. peak after, 387 +/- 85 pg/ml; P <0.05), and relaxed the proximal stomach (100% +/- 0% barostat volume vs. 202% +/- 15% volume; P <0.05). Exogenously administered gastrin also relaxed the proximal stomach without decreasing plasma glucose. CCK-B blockade diminished, but did not abolish, the gastric relaxation caused by insulin or gastrin, whereas CCK-A blockade had little effect. It was concluded that insulin-induced relaxation of the proximal stomach after proximal gastric vagotomy is mediated, in part, by vagal release of antral gastrin.

Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Publishing Authors By Initials

H Morimoto,KA Kelly,

For similar surgical procedures, operative: neurosurgical procedures: denervation: autonomic denervation: parasympathectomy: vagotomy: vagotomy, proximal gastric research abstracts see: surgical procedures, operative: neurosurgical procedures: denervation: autonomic denervation: parasympathectomy: vagotomy: vagotomy, proximal gastric research

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Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of gastrointestinal surgery : official jou

VOLUME: 1

Page Numbers: 386-94

Journal Abbreviation: J. Gastrointest. Surg.

ISSN: 1091-255X

DAY: 3

MONTH: 12

YEAR: 2007

Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9706084

Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Keywords Mesh Terms:

KEYWORDS: Vagotomy, Proximal Gastric

MESH TERMS: physiology

Chemical & Substance for Abstract: Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Mechanisms of insulin-induced relaxation of the canine proximal stomach after proximal gastric vagotomy.

AFFILIATION: Department of Surgery and the Samuel C. Johnson Medical Research Center, Mayo Clinic Scottsdale, Scottsdale, Ariz, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK18278

ACRONYM: DK

MEDLINETA: J Gastrointest Surg

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