Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis.

Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Research Abstract Details 

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Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Abstract Text:

Beth A Carter,Robert J Shulman,

Since its introduction into clinical practice, parenteral nutrition has revolutionized the care of premature neonates. Serum transaminase and bilirubin levels are commonly elevated in infants on parenteral nutrition, but their normalization is typical in the setting of short-term administration of parenteral nutrition uncomplicated by sepsis. Premature infants who require long-term parenteral nutrition are, however, at severe risk for developing life-threatening hepatic complications. These complications include cirrhosis, liver failure, and the concomitant risks of sepsis, coagulopathy and death. Premature infants and those with short-bowel syndrome are most susceptible to these morbid outcomes. Although it has been more than a quarter of a century since parenteral nutrition was first introduced and its association with hepatic complications described, the precise etiology of parenteral nutrition associated cholestasis (PNAC) remains a mystery; however, our understanding of the molecular components that contribute to PNAC has improved substantially. In this Review, we summarize the fundamentals of PNAC, describe animal models of the disease, review the hepatic bile acid transporters that are crucial for bile acid homeostasis, and define the roles that endotoxin, genetics, and the components of parenteral nutrition are likely to have in the molecular pathogenesis of this life-threatening condition.

Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Publishing Authors By Initials

BA Carter,RJ Shulman,

For similar therapeutics: feeding methods: parenteral nutrition research abstracts see: therapeutics: feeding methods: parenteral nutrition research

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Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature clinical practice. Gastroenterology & hepat

VOLUME: 4

Page Numbers: 277-87

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ISSN: 1743-4386

DAY: 3

MONTH: May

YEAR: 2007

Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Information

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LANGUAGE: eng

NlmUniqueID: 101226510

Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis. Keywords Mesh Terms:

KEYWORDS: Parenteral Nutrition

MESH TERMS: adverse effects

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Grant and Affiliation Information for Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis.

AFFILIATION: Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine, Houston, TX 77030, USA. bac@bcm.tmc.edu

Country: England

AGENCY: United States NICHD

GRANT: K12 HD41648-04

ACRONYM: HD

MEDLINETA: Nat Clin Pract Gastroenterol H

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