Mechanisms of cancer chemoprevention by curcumin.

Mechanisms of cancer chemoprevention by curcumin. Research Abstract Details 

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Mechanisms of cancer chemoprevention by curcumin. Abstract Text:

Curcumin is a major component of the Curcuma species, which is commonly used as a yellow coloring and flavoring agent in foods. Curcumin has shown anti-carcinogenic activity in animals as indicated by its ability to block colon tumor initiation by azoxymethane and skin tumor promotion induced by phorbol ester TPA. Recently, curcumin has been considered by oncologists as a potential third generation cancer chemopreventive agent, and clinical trials using it have been carried out in several laboratories. Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes, such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase. Curcumin is also a potent inhibitor of protein kinase C, EGF-receptor tyrosine kinase and IkappaB kinase. In addition, curcumin inhibits the activation of NFkappaB and the expression of c-jun, c-fos, c-myc and iNOS. It is proposed that curcumin may suppress tumor promotion by blocking signal transduction pathways in the target cells. Curcumin was first biotransformed to dihydrocurcumin and tetrahydrocurcumin, and these compounds were subsequently convened into monoglucuronide conjugates. The experimental results suggest that curcumin-glucuronide, dihydrocurcumin-glucuronide, tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are major metabolites of curcumin in mice.

Mechanisms of cancer chemoprevention by curcumin. Publishing Authors By Initials

For similar neoplasms: neoplasms, experimental research abstracts see: neoplasms: neoplasms, experimental research

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Mechanisms of cancer chemoprevention by curcumin. Journal Published:

PUBLICATION TYPE: Review

Journal: Proceedings of the National Science Council, Repub

VOLUME: 25

Page Numbers: 59-66

Journal Abbreviation: Proc. Natl. Sci. Counc. Repub.

ISSN: 0255-6596

DAY: 26

MONTH: Apr

YEAR: 2001

Mechanisms of cancer chemoprevention by curcumin. Information

Number of References: 34

LANGUAGE: eng

NlmUniqueID: 8502426

Mechanisms of cancer chemoprevention by curcumin. Keywords Mesh Terms:

KEYWORDS: Neoplasms, Experimental

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Mechanisms of cancer chemoprevention by curcumin. Information

Substance Name: Curcumin

Registry Number: 458-37-7

Grant and Affiliation Information for Mechanisms of cancer chemoprevention by curcumin.

AFFILIATION: Institute of Biochemistry, College of Medicine, National Taiwan University, Taipei, ROC.

Country: China (Republic: 1949- )

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MEDLINETA: Proc Natl Sci Counc Repub Chin

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