Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease.

Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease. Research Abstract Details 

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Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease. Abstract Text:

Peter J Crouch,Susan-Marie E Harding,Anthony R White,James Camakaris,Ashley I Bush,Colin L Masters,Peter J Crouch,Susan-Marie E Harding,Anthony R White,James Camakaris,Ashley I Bush,Colin L Masters,Peter J Crouch,Susan-Marie E Harding,Anthony R White,James Camakaris,Ashley I Bush,Colin L Masters,

Development of a comprehensive therapeutic treatment for the neurodegenerative Alzheimer's disease (AD) is limited by our understanding of the underlying biochemical mechanisms that drive neuronal failure. Numerous dysfunctional mechanisms have been described in AD, ranging from protein aggregation and oxidative stress to biometal dyshomeostasis and mitochondrial failure. In this review we discuss the critical role of amyloid-beta (Abeta) in some of these potential mechanisms of neurodegeneration. The 39-43 amino acid Abeta peptide has attracted intense research focus since it was identified as a major constituent of the amyloid deposits that characterise the AD brain, and it is now widely recognised as central to the development of AD. Familial forms of AD involve mutations that lead directly to altered Abeta production from the amyloid-beta A4 precursor protein, and the degree of AD severity correlates with specific pools of Abeta within the brain. Abeta contributes directly to oxidative stress, mitochondrial dysfunction, impaired synaptic transmission, the disruption of membrane integrity, and impaired axonal transport. Further study of the mechanisms of Abeta mediated neurodegeneration will considerably improve our understanding of AD, and may provide fundamental insights needed for the development of more effective therapeutic strategies.

Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease. Publishing Authors By Initials

PJ Crouch,SM Harding,AR White,J Camakaris,AI Bush,CL Masters,PJ Crouch,SM Harding,AR White,J Camakaris,AI Bush,CL Masters,PJ Crouch,SM Harding,AR White,J Camakaris,AI Bush,CL Masters,

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Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The international journal of biochemistry & cell b

VOLUME: 40

Page Numbers: 181-98

Journal Abbreviation: Int. J. Biochem. Cell Biol.

ISSN: 1357-2725

DAY: 1

MONTH: 08

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9508482

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AFFILIATION: Department of Pathology, The University of Melbourne, Victoria 3010, Australia; Centre for Neuroscience, The University of Melbourne, Victoria 3010, Australia; Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia.

Country: England

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MEDLINETA: Int J Biochem Cell Biol

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