Mechanisms in the regulation of aromatase in developing ovary and placenta.

Mechanisms in the regulation of aromatase in developing ovary and placenta. Research Abstract Details 

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Mechanisms in the regulation of aromatase in developing ovary and placenta. Abstract Text:

Carole R Mendelson,Amrita Kamat,

During human gestation, the placental syncytiotrophoblast develops the capacity to synthesize large amounts of estrogen from C(19)-steroids secreted by the fetal adrenals. The conversion of C(19)-steroids to estrogens is catalyzed by aromatase P450 (P450arom), product of the CYP19 gene. The placenta-specific promoter of the hCYP19 gene lies approximately 100,000 bp upstream of the translation initiation site in exon II. In studies using transgenic mice and transfected human trophoblast cells we have defined a 246-bp region upstream of placenta-specific exon I.1 that mediates placental cell-specific expression. Using transgenic mice, we also observed that as little as 278 bp of DNA flanking the 5'-end of ovary-specific hCYP19 exon IIa was sufficient to target ovary-specific expression. This ovary-specific promoter contains response elements that bind cAMP-response element-binding protein (CREB) and the orphan nuclear receptors SF-1 and LRH-1, which are required for cAMP-mediated stimulation of CYP19 expression in granulosa and luteal cells during the estrous cycle and pregnancy. In this article, we review our studies to define genomic regions and response elements that mediate placenta-specific expression of the hCYP19 gene. The temporal and spatial expression of LRH-1 versus SF-1 in the developing gonad during mouse embryogenesis and in the postnatal ovary also will be considered.

Mechanisms in the regulation of aromatase in developing ovary and placenta. Publishing Authors By Initials

CR Mendelson,A Kamat,

For similar embryonic structures: placenta research abstracts see: embryonic structures: placenta research

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Mechanisms in the regulation of aromatase in developing ovary and placenta. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of steroid biochemistry and molecular

VOLUME: 106

Page Numbers: 62-70

Journal Abbreviation: J. Steroid Biochem. Mol. Biol.

ISSN: 0960-0760

DAY: 21

MONTH: 05

YEAR: 2007

Mechanisms in the regulation of aromatase in developing ovary and placenta. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9015483

Mechanisms in the regulation of aromatase in developing ovary and placenta. Keywords Mesh Terms:

KEYWORDS: Placenta

MESH TERMS: growth & development

Chemical & Substance for Abstract: Mechanisms in the regulation of aromatase in developing ovary and placenta. Information

Substance Name: Aromatase

Registry Number: EC 1.14.14.1

Grant and Affiliation Information for Mechanisms in the regulation of aromatase in developing ovary and placenta.

AFFILIATION: Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, TX 75390-9038, USA. carole.mendelson@utsouthwestern.edu

Country: England

AGENCY: United States NIDDK

GRANT: R01 DK-31206

ACRONYM: DK

MEDLINETA: J Steroid Biochem Mol Biol

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