Mechanisms, biology and inhibitors of deubiquitinating enzymes.

Mechanisms, biology and inhibitors of deubiquitinating enzymes. Research Abstract Details 

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Mechanisms, biology and inhibitors of deubiquitinating enzymes. Abstract Text:

Kerry Routenberg Love, Catic,Christian Schlieker,Hidde L Ploegh,Kerry Routenberg Love, Catic,Christian Schlieker,Hidde L Ploegh,

The addition of ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers to proteins serves to modulate function and is a key step in protein degradation, epigenetic modification and intracellular localization. Deubiquitinating enzymes and Ubl-specific proteases, the proteins responsible for the removal of Ub and Ubls, act as an additional level of control over the ubiquitin-proteasome system. Their conservation and widespread occurrence in eukaryotes, prokaryotes and viruses shows that these proteases constitute an essential class of enzymes. Here, we discuss how chemical tools, including activity-based probes and suicide inhibitors, have enabled (i) discovery of deubiquitinating enzymes, (ii) their functional profiling, crystallographic characterization and mechanistic classification and (iii) development of molecules for therapeutic purposes.

Mechanisms, biology and inhibitors of deubiquitinating enzymes. Publishing Authors By Initials

KR Love,A Catic,C Schlieker,HL Ploegh,KR Love,A Catic,C Schlieker,HL Ploegh,

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Mechanisms, biology and inhibitors of deubiquitinating enzymes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature chemical biology

VOLUME: 3

Page Numbers: 697-705

Journal Abbreviation: Nat. Chem. Biol.

ISSN: 1552-4469

DAY: 19

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 101231976

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Grant and Affiliation Information for Mechanisms, biology and inhibitors of deubiquitinating enzymes.

AFFILIATION: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Country: United States

AGENCY: United States NIAID

GRANT: F32 AI63854

ACRONYM: AI

MEDLINETA: Nat Chem Biol

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