Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.

Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Research Abstract Details 

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Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Abstract Text:

Chun-Min Lo,Liyun Ma,Dian Ming Zhang,Rachel Lee,Abby Qin,Min Liu,Stephen C Woods,Randall R Sakai,Helen E Raybould,Patrick Tso,

Many gastrointestinal meal-related signals are transmitted to the central nervous system via the vagus nerve and thereby control changes in meal size. The c-Fos-positive neuron has been used as a marker of neuronal activation after lipid meals to examine the contribution of a selective macronutrient on brain neurocircuit activity. In rats fed Intralipid, the c-Fos-positive neurons were highly stimulated in the nucleus of the solitary tract (NTS) and in the hypothalamus, including the paraventricular nucleus (PVN), arcuate nucleus of the hypothalamus (ARC), and ventromedial hypothalamus at 4 h lipid feeding. However, c-Fos-like immunoreactivity was markedly attenuated in these brain regions when chylomicron formation/secretion was blocked by Pluronic L-81. After lymph was diverted from the lymph cannulated animals, the rats had a lower number of c-Fos-positive cells in the NTS and ARC. In contrast, the rats had higher c-Fos-positive neurons in PVN. The present study also revealed that c-Fos-positive neurons induced by feeding of Intalipid were abolished by CCK type 1 receptor antagonist, Lorglumide. We conclude that the formation and/or secretion of chylomicron are critical steps for initiating neuronal activation in the brain.

Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Publishing Authors By Initials

CM Lo,L Ma,DM Zhang,R Lee,A Qin,M Liu,SC Woods,RR Sakai,HE Raybould,P Tso,

For similar hypothalamus, middle: ventromedial hypothalamic nucleus research abstracts see: hypothalamus, middle: ventromedial hypothalamic nucleus research

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Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Regulatory, integr

VOLUME: 292

Page Numbers: R268-73

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 21

MONTH: 09

YEAR: 2006

Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Information

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LANGUAGE: eng

NlmUniqueID: 100901230

Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Keywords Mesh Terms:

KEYWORDS: Ventromedial Hypothalamic Nucleus

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption. Information

Substance Name: lorglumide

Registry Number: 97964-56-2

Grant and Affiliation Information for Mechanism of the induction of brain c-Fos-positive neurons by lipid absorption.

AFFILIATION: Department of Pathology, University of Cincinnati, Cincinnati, OH 45237, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK-56910

ACRONYM: DK

MEDLINETA: Am J Physiol Regul Integr Comp

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