Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study.

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Abstract Text:

Madison S Spach,J Francis Heidlage,Paul C Dolber,Roger C Barr,Madison S Spach,J Francis Heidlage,Paul C Dolber,Roger C Barr,

BACKGROUND: Aging is associated with a significant increase in atrial tachyarrhythmias, especially atrial fibrillation. A macroscopic repolarization gradient created artificially by a stimulus at one site before a premature stimulus from a second site is widely considered to be part of the experimental protocol necessary for the initiation of such arrhythmias in the laboratory. How such gradients occur naturally in aging atrial tissue is unknown. OBJECTIVE: The objective of this study was to determine if the pattern of cellular connectivity in aging human atrial bundles produces a mechanism for variable early premature responses. METHODS: Extracellular and intracellular potentials were recorded after control and premature stimuli at a single site in aging human atrial bundles. We also measured cellular geometry, the distribution of connexins, and the distribution of collagenous septa. A model of the atrial bundles was constructed based on the morphological results. Action potential propagation and the sodium current were analyzed after premature stimuli in the model. RESULTS: Similar extracellular potential waveform responses occurred after early premature stimuli in the aging bundles and in the model. Variable premature conduction patterns were accounted for by the single model of aging atrial structure. A major feature of the model results was that the conduction events and the magnitude of the sodium current at multiple sites were very sensitive to small changes in the location and the timing of premature stimuli. CONCLUSION: In aging human atrial bundles stimulated from only a single site, premature stimuli induce variable arrhythmogenic conduction responses. The generation of these responses is greatly enhanced by remodeling of cellular connectivity during aging. The results provide insight into sodium current structural interactions as a general mechanism of arrhythmogenic atrial responses to premature stimuli.

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Publishing Authors By Initials

MS Spach,JF Heidlage,PC Dolber,RC Barr,MS Spach,JF Heidlage,PC Dolber,RC Barr,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Heart rhythm : the official journal of the Heart R

VOLUME: 4

Page Numbers: 175-85

Journal Abbreviation:

ISSN: 1547-5271

DAY: 1

MONTH: 11

YEAR: 2006

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101200317

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study.

AFFILIATION: Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA. cspach@duke.edu

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL050537-10

ACRONYM: HL

MEDLINETA: Heart Rhythm

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study Related Publications

• Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells.
• Analysis of genetic events that modulate the oncogenic and growth suppressive activities of the PAX3-FKHR fusion oncoprotein.
• Annual report of the National Influenza Surveillance Scheme, 2006.
• Antihypertensive medications and C-reactive protein in the multi-ethnic study of atherosclerosis.
• Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm.
• Automated tracking of multiple C. Elegans.
• Bone mineral status after treatment of malignant lymphoma in childhood and adolescence.
• Bunyavirus mRNA synthesis is coupled to translation to prevent premature transcription termination.
• Diagnosis and management of sex anomalies.
• Duplex Doppler sonography of the carotid artery: velocity measurements in an artery with contralateral stenosis.
• Enhanced apoptosis in psoriatic plaques after treatment with propylthiouracil.
• Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders.
• Functional dissection of Rab GTPases involved in primary cilium formation.
• Fusions involving PAX and FOX genes in the molecular pathogenesis of alveolar rhabdomyosarcoma: recent advances.
• Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study.
• In utero exposure to DDT and performance on the Brazelton neonatal behavioral assessment scale.
• Interprofessional education: the fourth focus.
• Mechanism of origin of conduction disturbances in aging human atrial bundles: experimental and model study.
• Method for determination of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea and propylenethiourea in human urine using high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry.
• Multisite interstitial stimulation for cardiac micro-impedance measurements.
• Proceedings of a workshop: bridging the gap in care and addressing participation in clinical trials.
• Progression and regression of incident cervical HPV 6, 11, 16 and 18 infections in young women.
• Prospective study of short stature and newly diagnosed asthma in women.
• Soft-tissue injury caused by antineoplastic drugs is inhibited by topical dimethyl sulphoxide and alpha tocopherol.
• Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.
• Spinal cord ionotropic glutamate receptors function in formalin-induced nociception in preweaning rats.
• Stroke outcome in patients already taking aspirin.
• The challenges for nurses communicating with and gaining valid consent from adults with intellectual disabilities within the accident and emergency care service.
• The use of clinical simulation systems to train critical care physicians.
• The value of laryngeal electromyography in the evaluation of laryngeal motion abnormalities.