Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics.

Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Research Abstract Details 

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Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Abstract Text:

Shoichiro Ono,

The actin cytoskeleton is one of the major structural components of the cell. It often undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular processes, including cell migration, cytokinesis, membrane trafficking, and morphogenesis. Actin monomers are polymerized into filaments under physiological conditions, but spontaneous depolymerization is too slow to maintain the fast actin filament dynamics observed in vivo. Gelsolin, actin-depolymerizing factor (ADF)/cofilin, and several other actin-severing/depolymerizing proteins can enhance disassembly of actin filaments and promote reorganization of the actin cytoskeleton. This review presents advances as well as a historical overview of studies on the biochemical activities and cellular functions of actin-severing/depolymerizing proteins.

Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Publishing Authors By Initials

S Ono,

For similar cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: cytoskeleton: microfilaments research abstracts see: cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: cytoskeleton: microfilaments research

PUBMED ID PMID:

MEDLINE DATE:

Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Journal Published:

PUBLICATION TYPE: Review

Journal: International review of cytology

VOLUME: 258

Page Numbers: 1-82

Journal Abbreviation: Int. Rev. Cytol.

ISSN: 0074-7696

DAY: 3

MONTH: 12

YEAR: 2007

Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Information

Number of References: 626

LANGUAGE: eng

NlmUniqueID: 2985180

Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Keywords Mesh Terms:

KEYWORDS: Microfilaments

MESH TERMS: metabolism

Chemical & Substance for Abstract: Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Information

Substance Name: Actins

Registry Number: 0

Grant and Affiliation Information for Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics.

AFFILIATION: Department of Pathology, Emory University, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR 48615

ACRONYM: AR

MEDLINETA: Int Rev Cytol

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