Mechanical strain regulates endothelial cell patterning in vitro.

Mechanical strain regulates endothelial cell patterning in vitro. Research Abstract Details 

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Mechanical strain regulates endothelial cell patterning in vitro. Abstract Text:

Takuya Matsumoto,Yu Ching Yung,Claudia Fischbach,Hyun Joon Kong,Ryusuke Nakaoka,David J Mooney,

Blood vessels of the vertebrate circulatory system typically exhibit tissue-specific patterning. However, the cues that guide the development of these patterns remain unclear. We investigated the effect of cyclic uniaxial strain on vascular endothelial cell dynamics and sprout formation in vitro in two-dimensional (2D) and three-dimensional (3D) culture systems under the influence of growth factors. Cells preferentially aligned and moved in the direction perpendicular to the major strain axis in monolayer culture, and mechanical strain also regulated the spatial location of cell proliferation in 2D cell culture. Cells in 3D cell culture could be induced to form sprouts by exposure to appropriate growth factor combinations (vascular endothelial growth factor and hepatocyte growth factor), and the strain direction regulated the directionality of this process. Moreover, cyclic uniaxial strain inhibited branching of the structures formed by endothelial cells and increased their thickness. Taken together, these data support the importance of external mechanical stimulation in the regulation of endothelial cell migration, proliferation, and differentiation into primitive vessels.

Mechanical strain regulates endothelial cell patterning in vitro. Publishing Authors By Initials

T Matsumoto,YC Yung,C Fischbach,HJ Kong,R Nakaoka,DJ Mooney,

For similar cardiovascular system: blood vessels: veins: portal system: umbilical veins research abstracts see: cardiovascular system: blood vessels: veins: portal system: umbilical veins research

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Mechanical strain regulates endothelial cell patterning in vitro. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Tissue engineering

VOLUME: 13

Page Numbers: 207-17

Journal Abbreviation: Tissue Eng.

ISSN: 1076-3279

DAY: 3

MONTH: Jan

YEAR: 2007

Mechanical strain regulates endothelial cell patterning in vitro. Information

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LANGUAGE: eng

NlmUniqueID: 9505538

Mechanical strain regulates endothelial cell patterning in vitro. Keywords Mesh Terms:

KEYWORDS: Umbilical Veins

MESH TERMS: physiology

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Grant and Affiliation Information for Mechanical strain regulates endothelial cell patterning in vitro.

AFFILIATION: Division of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. tmatsu@dent.osaka-u.ac.jp

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL069957

ACRONYM: HL

MEDLINETA: Tissue Eng

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