Mechanical properties of bone and skin during recovery after cyclophosphamide administration.

Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Research Abstract Details 

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Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Abstract Text:

H Wie,E I Beck,L B Engesaeter,N Langeland,

The effects of cyclophosphamide were studied 2, 5 and 9 days after terminating a two-week every-second-day intraperitoneal medication in young, male rats. The cytostatic effect was assessed by counting white blood cells (WBC) in arterial blood. WBC counts were reduced by 72% of control values at 2 days and regained normal values at 9 days after an overshooting leucocytosis at 5 days. Compared to control animals, the treated rats had significantly reduced body weights, metaphyseal bending strength and longitudinal growth of the femur at all time intervals observed. The torsional strength of the femur diaphysis and the strength of wounded skin were not affected at 2 days, but significantly reduced at 5 and 9 days. The tensile strength of intact skin was not found to be affected by the drug. From the 5th to the 9th day after ending medication, the curves for control and treated animals were assuming parallel slopes regarding metaphyseal bone strength, longitudinal bone growth and tensile strength of wounds. This may indicate reversion of the drug effects approximately one week after terminating medication.

Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Publishing Authors By Initials

H Wie,EI Beck,LB Engesaeter,N Langeland,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

PUBMED ID PMID:

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Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of orthopaedic and traumatic surgery. Arc

VOLUME: 101

Page Numbers: 83-7

Journal Abbreviation:

ISSN: 0344-8444

DAY: 21

MONTH: 02

YEAR: 1983

Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803037

Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: drug effects

Chemical & Substance for Abstract: Mechanical properties of bone and skin during recovery after cyclophosphamide administration. Information

Substance Name: Cyclophosphamide

Registry Number: 50-18-0

Grant and Affiliation Information for Mechanical properties of bone and skin during recovery after cyclophosphamide administration.

AFFILIATION:

Country: GERMANY, WEST

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ACRONYM:

MEDLINETA: Arch Orthop Trauma Surg

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