Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma.

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Abstract Text:

J M Phillips,R S Ehrlichman,S J Siegel,

Cigarette smoking is significantly more prevalent in individuals with schizophrenia than in non-affected populations. Certain neurocognitive deficits and disruptions common in schizophrenia may be altered by smoking, leading to the hypothesis that schizophrenics engage in smoking behavior to alleviate specific neurocognitive symptoms of the disorder. Additionally, research suggests that individuals with schizophrenia have altered auditory event-related potentials (ERPs) and abnormalities in evoked gamma oscillations which are both indices of sensory information processing. This study was conducted to examine the effect of acute administration of nicotine and the non-specific nicotinic antagonist mecamylamine on the P20 and N40 components of the ERP and evoked gamma oscillations in mice. Acute nicotine (1 mg/kg) significantly increased P20 amplitude, an effect that was blocked by pretreatment with mecamylamine (2 mg/kg). Additionally, acute nicotine increased the normal burst of evoked gamma following an auditory stimulus. The increase in evoked gamma was also blocked by mecamylamine pretreatment. Although acute nicotine decreased amplitude of the N40 component, this decrease was not attenuated by mecamylamine. These results replicate findings that nicotine may enhance early sensory information processing through the nicotinic acetylcholinergic receptor system in an established model (ERPs) and extend these findings in an emerging, novel model (evoked gamma oscillations) of sensory information processing. The results also support the hypothesis that nicotine may be beneficial to individuals with deficits in neurocognitive functions, such as those suffering from schizophrenia.

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Publishing Authors By Initials

JM Phillips,RS Ehrlichman,SJ Siegel,

For similar disorders of environmental origin: substance-related disorders: tobacco use disorder research abstracts see: disorders of environmental origin: substance-related disorders: tobacco use disorder research

PUBMED ID PMID:

MEDLINE DATE:

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience

VOLUME: 144

Page Numbers: 1314-23

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 19

MONTH: 12

YEAR: 2006

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Keywords Mesh Terms:

KEYWORDS: Tobacco Use Disorder

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Information

Substance Name: Mecamylamine

Registry Number: 60-40-2

Grant and Affiliation Information for Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma.

AFFILIATION: Department of Psychiatry, University of Pennsylvania, Translational Research Laboratories, Room 2223, 125 South 31st Street, Philadelphia, PA 19104, USA.

Country: United States

AGENCY: United States NIMH

GRANT: P50 MH064045-065134

ACRONYM: MH

MEDLINETA: Neuroscience

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma Related Publications

• Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits.
• Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture.
• At what age can children report dependably on their asthma health status?
• Attentional modulation of receptive field structure in area 7a of the behaving monkey.
• Autoimmunity versus tolerance: can dying cells tip the balance?
• Effect of the ovulatory cycle on oviductal sperm storage in the domestic fowl.
• Effects of glossopharyngeal insufflation on cardiac function: an echocardiographic study in elite breath-hold divers.
• Fighting cancer with fitness: dietary outcomes of a randomized, controlled lifestyle change intervention in healthy African-American women.
• Hypocretin (orexin) cell loss in Parkinson's disease.
• Informatics in radiology: GridCAD: grid-based computer-aided detection system.
• Integration of hydrogels with hard and soft microstructures.
• Large germline deletions and duplication in isolated cerebral cavernous malformation patients.
• MDCT of tracheobronchial narrowing in pediatric patients.
• Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma.
• MedlinePlus and the challenge of low health literacy: findings from the Colonias project.
• Mortality partitions and their relevance to research on senescence.
• Onset of puberty in CD-1 mouse pups exposed prenatally through weaning to endophyte-infected tall fescue seed.
• Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway.
• Phage display-based molecular methods in immunohematology.
• Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits.
• Pneumonitis in human cytomegalovirus infection.
• Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.
• Premature carotid artery disease in long-term survivors of childhood cancer treated with neck irradiation: a series of 5 cases.
• Reproducibility of platelet function testing.
• Sexual violence inside prisons: rates of victimization.
• Stress and health: psychological, behavioral, and biological determinants.
• The effects of yoga practice on psychological well-being: 2426: board #105 june 1 3:30 PM -5:00 PM.
• The neurobiology of aggression and rage: role of cytokines.
• Trends in the inpatient mental health treatment of children and adolescents in US community hospitals between 1990 and 2000.
• Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer.