Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia.

Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Research Abstract Details 

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Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Abstract Text:

Siew Fah Yeo,Sharon Huie,Andre N Sofair,Sheldon Campbell,Amanda Durante,Brian Wong,

D-Arabinitol (DA) is a useful diagnostic marker for candidiasis in patients with neutropenia and other high-risk groups, but its use in unselected patients with a broad range of underlying diseases and conditions has not been studied. We used an automated enzymatic fluorometric assay to measure serum DA/creatinine ratios (DA/cr's) in 30 healthy adults, 100 hospitalized controls without Candida fungemia, and 83 patients from a study of all Candida fungemias in Connecticut between October 1998 and September 1999. Sixty-three of 83 (76%) fungemic patients and 11 of 100 (11%) nonfungemic controls had serum DA/cr's >or=3.9 microM/mg/dl (mean + 3 standard deviations for 30 healthy adults). High serum DA/cr's were less frequent in patients with cancer or fungemia caused by the DA nonproducer Candida glabrata than in patients with cancer or fungemia caused by a DA producer, C. albicans, C. tropicalis, or C. parapsilosis. The serum DA/cr was first >or=3.9 microM/mg/dl before, on the same day as, or after the first positive blood culture was drawn for 30 (36%), 22 (27%), and 11 (13%) fungemia patients, respectively. Mortality did not differ significantly among the patients with high or normal initial or peak serum DA/cr's, but mortality was higher if any serum DA/cr value was >or=3.9 microM/mg/dl 3 or more days after the onset of fungemia (18/27 versus 4/24 patients, respectively; P < 0.001). We conclude that serum DA/cr's are useful both for the initial diagnosis of Candida fungemia and for prognostic purposes for unselected patients with a broad range of underlying diseases and conditions.

Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Publishing Authors By Initials

SF Yeo,S Huie,AN Sofair,S Campbell,A Durante,B Wong,

For similar organic chemicals: alcohols: sugar alcohols research abstracts see: organic chemicals: alcohols: sugar alcohols research

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Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of clinical microbiology

VOLUME: 44

Page Numbers: 3894-9

Journal Abbreviation: J. Clin. Microbiol.

ISSN: 0095-1137

DAY: 6

MONTH: 09

YEAR: 2006

Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505564

Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Keywords Mesh Terms:

KEYWORDS: Sugar Alcohols

MESH TERMS: blood

Chemical & Substance for Abstract: Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia.

AFFILIATION: Infectious Diseases Section, VA Connecticut Healthcare System, West Haven, Connecticut, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI-57060

ACRONYM: AI

MEDLINETA: J Clin Microbiol

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