Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T.

Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Research Abstract Details 

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Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Abstract Text:

S G Mueller,L Stables,A T Du,N Schuff,D Truran,N Cashdollar,M W Weiner,

Histological studies suggest that hippocampal subfields are differently affected by aging and Alzheimer's disease (AD). The aims of this study were: (1) To test if hippocampal subfields can be identified and marked using anatomical landmarks on high resolution MR images obtained on a 4T magnet. (2) To test if age-specific volume changes of subfields can be detected. Forty-two healthy controls (21-85 years) and three AD subjects (76-86 years) were studied with a high resolution T2 weighted fast spin echo sequence. The entorhinal cortex (ERC), subiculum, CA1, CA2 and CA3/4 and dentate were marked. A significant correlation between age and CA1 (r=-0.51, p=0.0002) which was most pronounced in the seventh decade of life was found in healthy controls. In AD subjects, CA1 and subiculum were smaller than in age-matched controls. These preliminary findings suggest that measurement of hippocampal subfields may be helpful to distinguish between normal aging and AD.

Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Publishing Authors By Initials

SG Mueller,L Stables,AT Du,N Schuff,D Truran,N Cashdollar,MW Weiner,

For similar behavioral disciplines and activities: psychological tests: neuropsychological tests research abstracts see: behavioral disciplines and activities: psychological tests: neuropsychological tests research

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Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 719-26

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 19

MONTH: 05

YEAR: 2006

Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Information

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LANGUAGE: eng

NlmUniqueID: 8100437

Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T. Keywords Mesh Terms:

KEYWORDS: Neuropsychological Tests

MESH TERMS: physiology

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Grant and Affiliation Information for Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T.

AFFILIATION: Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs (DVA) Medical Center, Clement Street 4150, San Francisco, CA 94121, United States.

Country: United States

AGENCY: United States NIA

GRANT: R01 AG010897-21

ACRONYM: AG

MEDLINETA: Neurobiol Aging

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