Measles virus V protein inhibits p53 family member p73.

Measles virus V protein inhibits p53 family member p73. Research Abstract Details 

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Measles virus V protein inhibits p53 family member p73. Abstract Text:

Cristian D Cruz,Heidi Palosaari,Jean-Patrick Parisien,Patricia Devaux,Roberto Cattaneo,Toru Ouchi,Curt M Horvath,

Paramyxovirus V proteins function as host interference factors that inactivate antiviral responses, including interferon. Characterization of cellular proteins that copurify with ectopically expressed measles virus V protein has revealed interactions with DNA binding domains of p53 family proteins, p53 and p73. Specific transcriptional assays reveal that expression of measles virus V cDNA inhibits p73, but not p53. Expression of measles virus V cDNA can delay cell death induced by genotoxic stress and also can decrease the abundance of the proapoptotic factor PUMA, a p73 target. Recombinant measles virus with an engineered deficiency in V protein is capable of inducing more severe cytopathic effects than the wild type, implicating measles virus V protein as an inhibitor of cell death. These findings also suggest that p73-PUMA signaling may be a previously unrecognized arm of cellular innate antiviral immunity.

Measles virus V protein inhibits p53 family member p73. Publishing Authors By Initials

CD Cruz,H Palosaari,JP Parisien,P Devaux,R Cattaneo,T Ouchi,CM Horvath,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Measles virus V protein inhibits p53 family member p73. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 80

Page Numbers: 5644-50

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 3

MONTH: Jun

YEAR: 2006

Measles virus V protein inhibits p53 family member p73. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Measles virus V protein inhibits p53 family member p73. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Measles virus V protein inhibits p53 family member p73. Information

Substance Name: tumor suppressor protein p73

Registry Number: 0

Grant and Affiliation Information for Measles virus V protein inhibits p53 family member p73.

AFFILIATION: Pancoe-ENH Research Pavilion, Northwestern University, 2200 Campus Drive, Evanston, IL 60208, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 63476

ACRONYM: AI

MEDLINETA: J Virol

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