MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Research Abstract Details 

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MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Abstract Text:

Alberto Visintin,Kristen A Halmen,Naseema Khan,Brian G Monks,Douglas T Golenbock,Egil Lien,

The cell surface receptor complex formed by TLR4 and myeloid differentiation 2 (MD-2) is engaged when cells are exposed to LPS. Recent studies suggested that surface localization of functional mouse TLR4 (mTLR4) depends on the simultaneous expression of MD-2. As we did not observe a similar requirement, we conducted a comparative study of human TLR4 and mTLR4 surface expression in immune cells derived from the MD-2 knockout mouse and LPS-responsive cell lines and in cells that ectopically express TLR4. Our results indicate that in the human and mouse models, neither TLR4 function nor TLR4 surface targeting requires MD-2 coexpression. Accordingly, we report on one human cell line, which constitutively expresses functional TLR4 on the cell surface in the absence of MD-2 expression.

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Publishing Authors By Initials

A Visintin,KA Halmen,N Khan,BG Monks,DT Golenbock,E Lien,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, pattern recognition: toll-like receptors: toll-like receptor 4 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, pattern recognition: toll-like receptors: toll-like receptor 4 research

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MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of leukocyte biology

VOLUME: 80

Page Numbers: 1584-92

Journal Abbreviation: J. Leukoc. Biol.

ISSN: 0741-5400

DAY: 31

MONTH: 08

YEAR: 2006

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Information

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LANGUAGE: eng

NlmUniqueID: 8405628

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Keywords Mesh Terms:

KEYWORDS: Toll-Like Receptor 4

MESH TERMS: metabolism

Chemical & Substance for Abstract: MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4). Information

Substance Name: Toll-Like Receptor 4

Registry Number: 0

Grant and Affiliation Information for MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).

AFFILIATION: Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, NRB, 370L, 364 Plantation Street, Worcester, MA 01605, USA. alberto.visintin@umassmed.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR 14466

ACRONYM: RR

MEDLINETA: J Leukoc Biol

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