Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?

Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Research Abstract Details 

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Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Abstract Text:

Anupama Ravi,Pallavi Garg,Shanthi V Sitaraman,

Matrix metalloproteinases (MMPs) are a family of Zn(2+)-dependent extracellular matrix (ECM) degrading endopeptidases that share common functional domains, activation mechanisms, and collectively have the capacity to degrade all types of ECM proteins. In addition to playing a central role in ECM turnover, MMPs proteolytically activate or degrade a variety of nonmatrix substrates including chemokines, cytokines, growth factors, and junctional proteins. Thus, they are increasingly recognized as critical players in inflammatory response. Indeed, accumulating data from several studies indicate that they are the predominant proteases involved in the pathogenesis of inflammatory bowel disease (IBD) via their influence on the function and migration of inflammatory cells, mucosal ulceration, as well as matrix deposition and degradation. Some MMPs are constitutively expressed and play a protective role in IBD through their effect on cellular homeostasis, while others are induced during inflammation-mediated tissue damage. This article focuses on the role of the various MMPs in IBD, discussing their physiologic and pathogenetic role in the context of intestinal defense, mucosal inflammatory response, and immune cell-epithelial interaction.

Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Publishing Authors By Initials

A Ravi,P Garg,SV Sitaraman,

For similar proteins: tissue inhibitor of metalloproteinases research abstracts see: proteins: tissue inhibitor of metalloproteinases research

PUBMED ID PMID:

MEDLINE DATE:

Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Journal Published:

PUBLICATION TYPE: Review

Journal: Inflammatory bowel diseases

VOLUME: 13

Page Numbers: 97-107

Journal Abbreviation: Inflamm. Bowel Dis.

ISSN: 1078-0998

DAY: 3

MONTH: Jan

YEAR: 2007

Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Information

Number of References: 125

LANGUAGE: eng

NlmUniqueID: 9508162

Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Keywords Mesh Terms:

KEYWORDS: Tissue Inhibitor of Metalloproteinases

MESH TERMS: physiology

Chemical & Substance for Abstract: Matrix metalloproteinases in inflammatory bowel disease: boon or a bane? Information

Substance Name: Matrix Metalloproteinases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?

AFFILIATION: Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK06411

ACRONYM: DK

MEDLINETA: Inflamm Bowel Dis

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