Matrix metalloproteinases and bone.

Matrix metalloproteinases and bone. Research Abstract Details 

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Matrix metalloproteinases and bone. Abstract Text:

Matrix metalloproteinases (MMPs) are members of a family of zinc-dependent proteolytic enzymes. Several of the MMPs are expressed at high levels in bone and cartilage in mammals including humans and mice and are capable of cleaving native, undenatured collagens with long uninterrupted triple helices; these MMPs therefore potentially function as collagenases in vivo. Several MMPs expressed in the skeleton appear to function in endochondral ossification during embryonic development and in modeling and remodeling of bone postnatally and later in life. Different functions of MMPs have been elucidated through observations of spontaneous mutations in MMP genes in humans and of targeted mutations in Mmp genes and collagen (substrate) genes in mice. Potential mechanisms to account for effects of these mutations are considered in this review.

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Matrix metalloproteinases and bone. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bone

VOLUME: 43

Page Numbers: 7-18

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 4

MONTH: 04

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Matrix metalloproteinases and bone.

AFFILIATION: Department of Medicine, Harvard Medical School and the Massachusetts General Hospital, Center for Immunology and Inflammatory Diseases, Building 149 13th Street, Room 8301, Boston. MA 02129, USA.

Country: United States

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MEDLINETA: Bone

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