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Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis.

Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Research Abstract Details 

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  • Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Abstract Text:

    maja zivkovi?Maja Zivkovi?,tamara djuri?Tamara Djuri?,evica dinci?Evica Dinci?,ranko raicevi?Ranko Raicevi?,dragan alavanti?Dragan Alavanti?,aleksandra stankovi?Aleksandra Stankovi?,

    Matrix metalloproteinase-9 (MMP-9) is suggested to play a role in MS by mediating T cell migration across subendothelial basement membrane and by contribution to myelin breakdown. We studied the association of MMP-9 -1562 C/T gene polymorphisms with MS susceptibility and severity in 187 patients from Serbia. The significant decrease in T allele carriership (p = 0.01), was found in female MS patients. In addition, a trend toward lower MSSS in T allele carriers was noticed (CC, mean 5.7 +/- 2.5 vs. CT+TT, mean 4.9 +/- 2.5). Further studies in different populations are needed to resolve the potential influence of MMP-9 gene polymorphism on MS.

    Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Publishing Authors By Initials

    m zivkovi?M Zivkovi?,t djuri?T Djuri?,e dinci?E Dinci?,r raicevi?R Raicevi?,d alavanti?D Alavanti?,a stankovi?A Stankovi?,

    For similar geographic locations: europe: europe, eastern: yugoslavia research abstracts see: geographic locations: europe: europe, eastern: yugoslavia research

    PUBMED ID PMID:

    MEDLINE DATE:

    Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: Journal of neuroimmunology

    VOLUME: 189

    Page Numbers: 147-50

    Journal Abbreviation: J. Neuroimmunol.

    ISSN: 0165-5728

    DAY: 25

    MONTH: 07

    YEAR: 2007

    Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Information

    Number of References:

    LANGUAGE: eng

    NlmUniqueID: 8109498

    Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Keywords Mesh Terms:

    KEYWORDS: Yugoslavia

    MESH TERMS: epidemiology

    Chemical & Substance for Abstract: Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis. Information

    Substance Name: Matrix Metalloproteinase 9

    Registry Number: EC 3.4.24.35

    Grant and Affiliation Information for Matrix metalloproteinase-9 -1562 C/T gene polymorphism in Serbian patients with multiple sclerosis.

    AFFILIATION: Vinca Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, Belgrade, Serbia. majaz@vin.bg.ac.yu

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: J Neuroimmunol

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