Matrix metalloproteinase 2: an important genetic marker for cholesteatomas.

Matrix metalloproteinase 2: an important genetic marker for cholesteatomas. Research Abstract Details 

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Matrix metalloproteinase 2: an important genetic marker for cholesteatomas. Abstract Text:

Douglas Salmazo Rocha Morales,Norma de Oliveira Penido,Ismael Dale Coltrin Guerreiro da Silva, ,Arnaldo Guilherme,Yotaka Fukuda,Douglas Salmazo Rocha Morales,Norma de Oliveira Penido,Ismael Dale Coltrin Guerreiro da Silva, ,Arnaldo Guilherme,Yotaka Fukuda,

AIM: This study is to determine the MMP2s presence in cholesteatomas and whether complicating cholesteatomas show a higher immunohistochemical expression of matrix metalloproteinase 2. Cholesteatoma produces enzymes that cause bone erosion like matrix metalloproteinase 2 (MMP2). MATERIAL AND METHODS: We analyzed the expression of MMP2 in invasive (causing complications) compared to latent cholesteatomas (not causing complications). A cross-sectional study with nineteen slides and paraffin blocks of cholesteatomas derived from mastoidectomies were located and processed, including 8 invasive and 11 latent cholesteatomas. Immunohistochemical technique was empregated to MMP2. RESULTS: The results are expressed as 0, + (to low), ++ and +++(high) according to the quantity and color of the immunohistochemical staining of MMP2. Higher expression of MMP2 was observed in 7 (87.5%) of the 8 invasive cholesteatomas. With respect to latent cholesteatomas, higher expression of MMP2 was observed in 27.3% (3 cases), with Fishers exact test indicating a significant difference (p=0.015). CONCLUSIONS: Cholesteatoamas express MMP2 and Invasive cholesteatomas had high MMP2 compared to latent cholesteatomas.

Matrix metalloproteinase 2: an important genetic marker for cholesteatomas. Publishing Authors By Initials

DS Morales,Nde Penido,ID da Silva,JN ,A Guilherme,Y Fukuda,DS Morales,Nde Penido,ID da Silva,JN ,A Guilherme,Y Fukuda,

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MEDLINE DATE: 2007 Jan-Feb

Matrix metalloproteinase 2: an important genetic marker for cholesteatomas. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Revista brasileira de otorrinolaringologia (Englis

VOLUME: 73

Page Numbers: 51-7

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ISSN: 1808-8694

DAY: 16

MONTH: 05

YEAR: 2007

Matrix metalloproteinase 2: an important genetic marker for cholesteatomas. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Matrix metalloproteinase 2: an important genetic marker for cholesteatomas.

AFFILIATION: University Hospital, USP, São Paulo, Brazil. douglas.morales@uol.com.br

Country: Brazil

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MEDLINETA: Rev Bras Otorrinolaringol (Eng

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