Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption.

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Abstract Text:

Hamish Dobbie,Robert J Unwin,Nuno J R Faria,David G Shirley,

BACKGROUND: Matrix extracellular phosphoglycoprotein (MEPE), first isolated from tumour-derived tissue from a patient with oncogenic hypophosphataemia, is a putative phosphatonin that has received much less attention than fibroblast growth factor-23. To date, its effect on renal tubular phosphate reabsorption remains undefined. METHODS: A renal clearance study was performed in anaesthetized rats infused intravenously with a range of doses of MEPE. RESULTS: MEPE had no effect on glomerular filtration rate (inulin clearance) but caused rapid, dose-dependent increases in absolute and fractional phosphate excretion, wholly attributable to reduced phosphate reabsorption. At a maximal dose, MEPE increased fractional phosphate excretion more than 2-fold, whereas no change was observed in time controls. CONCLUSION: The results lend support to the hypothesis that MEPE contributes to the phosphaturia of oncogenic hypophosphataemia and of hypophosphataemic rickets.

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Publishing Authors By Initials

H Dobbie,RJ Unwin,NJ Faria,DG Shirley,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nephrology, dialysis, transplantation : official p

VOLUME: 23

Page Numbers: 730-3

Journal Abbreviation: Nephrol. Dial. Transplant.

ISSN: 0931-0509

DAY: 23

MONTH: 11

YEAR: 2007

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8706402

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption.

AFFILIATION: Department of Physiology and Centre for Nephrology, University College London, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK. david.shirley@ucl.ac.uk.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nephrol Dial Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption Related Publications

• A 55-year-old man with right-sided weakness.
• An overview of divalent cation and citrate handling by the kidney.
• Autopsy rates at the University Hospital of the West Indies, 1968-1997.
• Behavior problems in pediatric practice.
• Beyond fibrocystic disease. The evolving concept of pre-malignant breast disease.
• CURRENT THINKING IN NUTRITION OF DENTAL TISSUES.
• Debate about non-heart beating organ donation.
• Development of a diagnostic PCR assay for the detection and discrimination of four pathogenic .Eimeria species of the chicken.
• Fibrolytic enzymes to increase the nutritive value of dairy feedstuffs.
• Matrix extracellular phosphoglycoprotein causes phosphaturia in rats by inhibiting tubular phosphate reabsorption.
• PEDIATRICIAN'S POINT OF VIEW.
• Revised formulas for diffraction effects with point and extended sources.
• Room-in for mothers and infants.
• Ruminal degradability and lysine bioavailability of soybean meals and effects on performance of dairy cows.
• Studies on the pathogenicity of chicken-maintained (virulent) and embryo-adapted (attenuated) strains of Eimeria Mivati.
• Survival in lung cancer.
• Testicular metastases from carcinoma of the prostate.
• The Safer Patients Initiative: the UK experience of attempting to improve safe clinical care.
• The control of hypertension by use of coconut water and mauby: two tropical food drinks.
• The development of collective moral leadership among parents through education organizing.
• The effect of vasopressin on renal blood flow and its distribution in the rat.
• The isolation of crystalline tennecetin and the comparison of this antibiotic with pimaricin.
• Time-of-flight photoelectron spectroscopy of gases using synchrotron radiation.