Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma.

Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Research Abstract Details 

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Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Abstract Text:

Ken D Stark,Robert J Pawlosky,Robert J Sokol,John H Hannigan,Norman Salem,

BACKGROUND: Maternal-fetal folate transport via the placenta has been shown to be concentrative. Exposure to cigarette smoke is associated with decreased maternal folate status through altered dietary intakes and possibly through nondietary mechanisms such as increased folate turnover. The effect of maternal smoking on fetal folate status has not been documented. OBJECTIVE: The objective was to determine the effect of maternal smoking on plasma 5-methyltetrahydrofolic acid (5-MTHFA) concentrations in umbilical cord blood. DESIGN: African American women were recruited from an antenatal clinic in Detroit, MI. Plasma 5-MTHFA concentrations were measured in maternal-umbilical cord pairings (n = 58). The participants completed a structured interview to determine demographic characteristics, including smoking. RESULTS: Concentrations of 5-MTHFA were significantly higher in venous cord plasma (16.8 +/- 7.5 ng/mL) than in maternal plasma (13.0 +/- 7.5 ng/mL) but remained associated (r = 0.60, P < 0.001) with each other. Cigarettes smoked by the mothers was negatively associated (r = -0.31, P = 0.019) with venous cord 5-MTHFA concentrations and remained so after control for maternal plasma 5-MTHFA and other variables. Venous cord plasma 5-MTHFA was significantly lower in smoking (15.1 +/- 7.6 ng/mL; n = 32) than in nonsmoking (19.0 +/- 7.0 ng/mL; n = 26) mothers. CONCLUSIONS: Cord plasma 5-MTHFA concentrations were elevated relative to maternal blood, as expected, because the placenta is capable of concentrative folate transport to the fetus. The negative effect of maternal smoking on infant, but not on maternal, 5-MTHFA status indicates that maternal smoking may impair folate transport to the fetus.

Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Publishing Authors By Initials

KD Stark,RJ Pawlosky,RJ Sokol,JH Hannigan,N Salem,

For similar cardiovascular system: blood vessels: veins: portal system: umbilical veins research abstracts see: cardiovascular system: blood vessels: veins: portal system: umbilical veins research

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Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The American journal of clinical nutrition

VOLUME: 85

Page Numbers: 796-802

Journal Abbreviation: Am. J. Clin. Nutr.

ISSN: 0002-9165

DAY: 3

MONTH: Mar

YEAR: 2007

Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376027

Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Keywords Mesh Terms:

KEYWORDS: Umbilical Veins

MESH TERMS: deficiency

Chemical & Substance for Abstract: Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma. Information

Substance Name: 5,10-methylenetetrahydrofolate

Registry Number: 3432-99-3

Grant and Affiliation Information for Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma.

AFFILIATION: Laboratory of Nutritional and Nutraceutical Research, Department of Kinesiology, University of Waterloo, Waterloo, ON, Canada. kstark@uwaterloo.ca

Country: United States

AGENCY: United States NIAAA

GRANT: N01-AA83019

ACRONYM: AA

MEDLINETA: Am J Clin Nutr

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