Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy.

Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. Research Abstract Details 

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Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. Abstract Text:

Francesca Gotsch,Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Shali Mazaki-Tovi,Offer Erez,Nandor Gabor Than,Samuel Edwin,Moshe Mazor,Bo Hyan Yoon,Sonia S Hassan,Francesca Gotsch,Roberto Romero,Jimmy Espinoza,Juan Pedro Kusanovic,Shali Mazaki-Tovi,Offer Erez,Nandor Gabor Than,Samuel Edwin,Moshe Mazor,Bo Hyan Yoon,Sonia S Hassan,

OBJECTIVE: Acute pyelonephritis is one of the most frequent medical complications of pregnancy, as well as a common cause of antepartum hospitalization. Interferon (IFN)-gamma inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with pro-inflammatory and anti-angiogenic properties. The purpose of this study was to determine whether maternal serum concentrations of CXCL10/IP-10 change in patients with acute pyelonephritis during pregnancy. STUDY DESIGN: This cross-sectional study was conducted to determine the difference in maternal serum concentrations of CXCL10/IP-10 in pregnant women with acute pyelonephritis (N = 41) and normal pregnant women (N = 89). Pyelonephritis was defined in the presence of a positive urine culture, fever, and maternal clinical signs; blood cultures were performed in 36 cases. Maternal serum concentrations of CXCL10/IP-10 were measured by a sensitive immunoassay. Non-parametric statistics were used for analysis. RESULTS: (1) The median serum concentration of CXCL10/IP-10 in pregnant patients with pyelonephritis was significantly higher than in normal pregnant women (median 318.5 pg/mL, range 78.8-2459.2 vs. median 116.1 pg/mL, range 40.7-1314.3, respectively; p < 0.001); (2) maternal median serum concentrations of CXCL10/IP-10 did not differ significantly among patients with acute pyelonephritis with and without bacteremia (positive blood cultures: median 362.6 pg/mL, range 100.2-2459.2 vs. negative blood cultures: median 298.9 pg/mL, range 108.5-1148.7, respectively; p = 0.3). CONCLUSIONS: Pyelonephritis in pregnant women is associated with an increased maternal serum concentration of the chemokine CXCL10/IP-10.

Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. Publishing Authors By Initials

F Gotsch,R Romero,J Espinoza,JP Kusanovic,S Mazaki-Tovi,O Erez,NG Than,S Edwin,M Mazor,BH Yoon,SS Hassan,F Gotsch,R Romero,J Espinoza,JP Kusanovic,S Mazaki-Tovi,O Erez,NG Than,S Edwin,M Mazor,BH Yoon,SS Hassan,

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Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: The journal of maternal-fetal & neonatal medicine

VOLUME: 20

Page Numbers: 735-44

Journal Abbreviation: J. Matern. Fetal. Neonatal. Me

ISSN: 1476-7058

DAY: 31

MONTH: Oct

YEAR: 2007

Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy. Information

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LANGUAGE: eng

NlmUniqueID: 101136916

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Grant and Affiliation Information for Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy.

AFFILIATION: Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland, USA.

Country: United States

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MEDLINETA: J Matern Fetal Neonatal Med

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