Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice.

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Abstract Text:

BACKGROUND AND OBJECTIVES: High dietary fat intake has been reported to cause an alteration in lipid metabolism that is associated with an increased risk of cardiovascular disease. In the present study, an animal model was used to evaluate the effects of feeding diets rich in different fatty acids to mothers during pregnancy and lactation, and the effects of the maternal diet on parameters of lipid metabolism in adult offspring. The interaction between the offspring's own diet and the programming due to the maternal diet was also evaluated. METHODS: Female C57BL/6 mice were fed a high-fat diet (20% fat [weight to weight]) rich in either saturated fatty acids (SFA) or polyunsaturated fatty acids (PUFA) for two weeks before mating, during pregnancy and until weaning. The offspring were divided into two groups; each group was fed a high-fat diet enriched in either SFA or PUFA for eight weeks after weaning. The groups were designated as SFA/SFA (diet of the mother/diet of the offspring), SFA/PUFA, PUFA/PUFA and PUFA/SFA. Blood and tissues were collected at the end of the eight-week feeding period after an overnight fast. RESULTS: The plasma total cholesterol and low density lipoprotein cholesterol concentrations were significantly higher in the SFA/SFA group than in all other groups, whereas the PUFA/PUFA group had the lowest total cholesterol and low density lipoprotein cholesterol concentrations. Plasma high density lipoprotein cholesterol concentrations were significantly higher in the PUFA/SFA group than in the PUFA/PUFA and SFA/PUFA groups, whereas plasma triglyceride concentrations were not different among the groups. CONCLUSIONS: The data suggest that high maternal dietary fat intake during pregnancy affects lipid metabolism in the adult offspring. However, it appears that the offspring's own diet is also important in maintaining the regulation of lipid metabolism.

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental and clinical cardiology

VOLUME: 11

Page Numbers: 129-35

Journal Abbreviation:

ISSN: 1205-6626

DAY: 24

MONTH: 07

YEAR: 2006

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9715903

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice.

AFFILIATION: Department of Biochemistry, Memorial University of Newfoundland, St John's, Newfoundland.

Country: Canada

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Clin Cardol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice Related Publications

• Candida fungal ball obstruction of the common bile duct.
• Cerebral venous thrombosis: analysis of a multicenter cohort from the United States.
• Colonisation, the New World Order, and the eradication of traditional food habits in East Africa: historical perspective on the nutrition transition.
• Maternal diet rich in saturated fats has deleterious effects on plasma lipids of mice.
• Merits of posterior lumbotomy approach to the upper urinary tract.
• Observations on the histopathology of warble infestation in goats by the larvae of Przhevalskiana silenus.
• Pectoralis major myocutaneous flap for reconstruction of defects following resections in head and neck area.
• Pre-operative renal function and selective renal vein renin levels as markers of favourable outcome in renovascular hypertension.
• Re: Transfusion protocol for implantation and explantation of cardiac devices in an Academic Medical Center.
• Reconstruction of thumb in traumatic or congenital loss.
• The suitability of 160Tb as a PAC probe for studies of biomolecules.
• Trace element analysis: a diagnostic tool.
• Transfer of latissimus dorsi muscle as myocutaneous flap.
• Utility of endoscopy in infantile hypertrophic pyloric stenosis.