Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex.

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Abstract Text:

T M Mayhew,H Jenkins,B Todd,V L Clifton,

Asthma is the most common respiratory disease to complicate pregnancy. Although adverse effects on the fetus have been documented, there is a paucity of information regarding the effects of asthma, and its treatment, on placental morphology. The aim of this study was to test for volumetric differences in placental composition between non-asthmatic pregnancies and those associated with maternal asthma grouped according to asthma severity and glucocorticoid (GC) treatment. Each placenta was weighed and random samples of tissue were fixed in formalin-saline, embedded in wax and analysed by design-based stereology. Volume densities of parenchymal compartments (peripheral villi and maternal intervillous space) and residual non-parenchyma were estimated by test point counting and converted to absolute volumes by taking into account placental size. Relative and absolute lengths of villi and capillaries were also estimated and used to derive secondary quantities related to villous capillarization and maturation. Between-group comparisons were drawn by two-way analysis of variance with group and fetal sex as the principal factors. Compared to non-asthmatic controls, asthmatics had reduced absolute volumes of fetal capillaries which was most marked in those with moderate/severe asthma and those using low and high doses of inhaled GCs. Changes in the total length and mean cross-sectional area of capillaries and peripheral villi were also observed. Lengths were greater in mild asthmatics and lowest in those with high GC usage. Calibre areas were lower in mild asthmatics and villous calibres in the high GC group were greater than those in asthmatics not taking GCs. Those making greatest use of inhaled GCs also had villi which were hypovascularized in terms of capillary:villus length ratios. The findings suggest that the morphometric differences in fetoplacental vascularity are likely to be due to the effects of asthma and use of inhaled GCs rather than the effects of maternal or fetal hypoxic stress.

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Publishing Authors By Initials

TM Mayhew,H Jenkins,B Todd,VL Clifton,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Placenta

VOLUME: 29

Page Numbers: 366-73

Journal Abbreviation: Placenta

ISSN: 0143-4004

DAY: 6

MONTH: 03

YEAR: 2008

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8006349

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex.

AFFILIATION: Centre for Integrated Systems Biology & Medicine, School of Biomedical Sciences, E Floor, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Placenta

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex Related Publications

• Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages.
• Back diffusion of hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis.
• Effect of carbohydrate distribution on postprandial glucose peaks with the use of continuous glucose monitoring in type 2 diabetes.
• Effect of intragastric bile salts on ionic movement across normal human gastric mucosa after intravenous atropine.
• Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity.
• Effects of weight loss on a low-carbohydrate diet on flow-mediated dilatation, adhesion molecules and adiponectin.
• Follow-up of a case of tuberculosis of the medical malleolus of the right tibia.
• Good agreement between bioelectrical impedance and dual-energy X-ray absorptiometry for estimating changes in body composition during weight loss in overweight young women.
• Growth and assimilation in cultures of Saccharomyces cerevisiae.
• HYPOTENSION ASSOCIATED WITH TETANUS.
• High dairy-protein versus high mixed-protein energy restricted diets - the effect on bone turnover and calcium excretion in overweight adults.
• Hormones and experimental oncogenesis: mammary and mammotropic tumors.
• How tough is bone? Application of elastic-plastic fracture mechanics to bone.
• Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance.
• Male sex and pre-existing diabetes are independent risk factors for stillbirth.
• Mammalian plasma membrane proteomics.
• Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma.
• Maternal asthma and placental morphometry: effects of severity, treatment and fetal sex.
• Metabolic effects of weight loss on a very-low-carbohydrate diet compared with an isocaloric high-carbohydrate diet in abdominally obese subjects.
• Reductions in blood pressure following energy restriction for weight loss do not rebound after re-establishment of energy balance in overweight and obese subjects.
• The effect of high- and low-glycemic index energy restricted diets on plasma lipid and glucose profiles in type 2 diabetic subjects with varying glycemic control.
• The effect of meal replacements high in glycomacropeptide on weight loss and markers of cardiovascular disease risk.
• The effect of milk protein on the bioavailability of cocoa polyphenols.
• The effect of protein source (dairy vs mixed) in high protein, energy restricted diets on body composition, vascular health and metabolic markers in overweight adults.
• Use of monolithic supports in proteomics technology.
• WO03/062224 is an in vivo selective agonist at nicotinic beta4 receptors.
• Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male Wistar rats.