Maternal antibrain antibodies in autism.

Maternal antibrain antibodies in autism. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Maternal antibrain antibodies in autism. Abstract Text:

Andrew W Zimmerman,Susan L Connors,Karla J Matteson,Li-Ching Lee,Harvey S Singer,Julian A Castaneda,David A Pearce,

Autism is a neurodevelopmental disorder of prenatal onset that is behaviorally defined. There is increasing evidence for systemic and neuroimmune mechanisms in children with autism. Although genetic factors are important, atypical prenatal maternal immune responses may also be linked to the pathogenesis of autism. We tested serum reactivity in 11 mothers and their autistic children, maternal controls, and several groups of control children, to prenatal, postnatal, and adult rat brain proteins, by immunoblotting. Similar patterns of reactivity to prenatal (gestational day 18), but not postnatal (day 8) or adult rat brain proteins were identified in autistic children, their mothers, and children with other neurodevelopmental disorders, and differed from mothers of normal children, normal siblings of children with autism and normal child controls. Specific patterns of antibody reactivity were present in sera from the autism mothers, from 2 to 18 years after the birth of their affected children and were unrelated to birth order. Immunoblotting using specific antigens for myelin basic protein (MBP) and glial acidic fibrillary protein (GFAP) suggests that these proteins were not targets of the maternal antibodies. The identification of specific serum antibodies in mothers of children with autism that recognize prenatally expressed brain antigens suggests that these autoantibodies could cross the placenta and alter fetal brain development.

Maternal antibrain antibodies in autism. Publishing Authors By Initials

AW Zimmerman,SL Connors,KJ Matteson,LC Lee,HS Singer,JA Castaneda,DA Pearce,

For similar reproductive and urinary physiology: reproduction: pregnancy research abstracts see: reproductive and urinary physiology: reproduction: pregnancy research

PUBMED ID PMID:

MEDLINE DATE:

Maternal antibrain antibodies in autism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain, behavior, and immunity

VOLUME: 21

Page Numbers: 351-7

Journal Abbreviation: Brain Behav. Immun.

ISSN: 0889-1591

DAY: 6

MONTH: 10

YEAR: 2006

Maternal antibrain antibodies in autism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8800478

Maternal antibrain antibodies in autism. Keywords Mesh Terms:

KEYWORDS: Pregnancy

MESH TERMS: immunology

Chemical & Substance for Abstract: Maternal antibrain antibodies in autism. Information

Substance Name: Nerve Tissue Proteins

Registry Number: 0

Grant and Affiliation Information for Maternal antibrain antibodies in autism.

AFFILIATION: Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA. zimmerman@kennedykrieger.org

Country: United States

AGENCY: United States NIEHS

GRANT: T32 ES07026-27

ACRONYM: ES

MEDLINETA: Brain Behav Immun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Maternal antibrain antibodies in autism Related Publications

• 1051.
• A dietary iodine questionnaire: correlation with urinary iodine and food diaries.
• Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells.
• Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis.
• Amnesic concentrations of the nonimmobilizer 1,2-dichlorohexafluorocyclobutane (F6, 2N) and isoflurane alter hippocampal theta oscillations in vivo.
• Association between glycosylated hemoglobin and cancer risk: a New Zealand linkage study.
• Channeling studies in yeast: yeast as a model for channelopathies?
• Commentary: The rise and rise of corporate epidemiology and the narrowing of epidemiology's vision.
• Cytokine Interaction and Immune Responses during Schistosoma mansoni Infection.
• Determination of the EC50 amnesic concentration of etomidate and its diffusion profile in brain tissue: implications for in vitro studies.
• Do antithyroid drugs influence outcome after radioiodine therapy for hyperthyroidism?
• Functional plasticity in memory T helper cell responses.
• Genetic progress towards the molecular basis of common autoimmunity.
• Influence of rearing conditions and respiratory disease on haptoglobin levels in the pig at slaughter.
• Lifelong farm exposure may strongly reduce the risk of asthma in adults.
• Maternal antibrain antibodies in autism.
• Memory CD4 T cells enhance primary CD8 T-cell responses.
• Myogenic contractility is more dependent on myofilament calcium sensitization in term fetal than adult ovine cerebral arteries.
• Parkinson's disease in the older patient.
• Postnatal maturation attenuates pressure-evoked myogenic tone and stretch-induced increases in Ca2+ in rat cerebral arteries.
• Preventing rotavirus gastroenteritis: do you have the facts?
• Progressive oxidative damage in the central nervous system of a murine model for juvenile Batten disease.
• Re: Adverse events and readmissions after day-case urological surgery.
• Structural learning and the hippocampus.
• Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells.
• TGF-beta signaling controls embryo development in the parasitic flatworm Schistosoma mansoni.
• Th1 and Th2 cells help CD8 T-cell responses.
• The practice of health care: wisdom as a model.
• Transfection of Schistosoma mansoni by electroporation and the description of a new promoter sequence for transgene expression.
• Use of Dronabinol Improves Appetite and Reverses Weight Loss in HIV/AIDS-Infected Patients.