Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma.

Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Research Abstract Details 

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Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Abstract Text:

The mechanisms contributing to worsening of asthma during pregnancy have not been well characterized. Both asthma and pregnancy are conditions associated with a skewing of the immune response from T helper (Th) 1 toward a Th2 response. We hypothesise that worsening of asthma during pregnancy may be due to an enhanced production of circulating proinflammatory cytokines and chemokines and this may be modified by the use of inhaled glucocorticoid treatment. Peripheral blood was collected from asthmatic (n=35) and control non-asthmatic patients (n=13) in the third trimester (30-37 weeks) of pregnancy. Fetal blood was collected from the umbilical vein of the placenta after delivery from normal (n=24) and pregnancies complicated by asthma (n=24). Plasma samples were assayed for IL-6, -8, eotaxin and RANTES using conventional ELISA. In addition, a range of Th1 and Th2 cytokines measured using Luminex system. There were no significant differences in the levels of maternal IL-6, IL-8, eotaxin and RANTES between asthmatics and nonasthmatics. The results of this study suggest that the presence of asthma does not result in an enhanced circulation of Th2 related cytokines and chemokines during the third trimester of pregnancy. Furthermore peripheral blood cytokine concentrations appear unaffected by inhaled glucocorticoid treatment. Cord plasma eotaxin concentrations were increased in pregnancies complicated by asthma, compared with control. This is the first study to show increased eotaxin production in the feto-placental unit of asthmatic pregnancies and may be one mechanism by which allergy susceptibility is increased in the offspring of asthmatic women.

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Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cytokine

VOLUME: 43

Page Numbers: 187-93

Journal Abbreviation: Cytokine

ISSN: 1096-0023

DAY: 17

MONTH: 07

YEAR: 2008

Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Maternal and cord plasma cytokine and chemokine profile in pregnancies complicated by asthma.

AFFILIATION: Mothers and Babies Research Centre, Department of Endocrinology, Locked Bag 1, Hunter Medical Research Institute, Newcastle NSW 2310, Australia.

Country: United States

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MEDLINETA: Cytokine

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