Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research.

Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Research Abstract Details 

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Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Abstract Text:

Julie A Panepinto,Mark C Walters,Jeanette Carreras,Judith Marsh,Christopher N Bredeson,Robert Peter Gale,Gregory A Hale,John Horan,Jill M Hows,John P Klein,Ricardo Pasquini,Irene Roberts,Keith Sullivan,Mary Eapen,Alina Ferster, ,

We report outcomes after myeloablative haematopoietic cell transplantation (HCT) from human leucocyte antigen (HLA)-matched sibling donors in 67 patients with sickle cell disease transplanted between 1989 and 2002. The most common indications for transplantation were stroke and recurrent vaso-occlusive crisis in 38% and 37% of patients respectively. The median age at transplantation was 10 years and 67% of patients had received >10 red blood cell transfusions before HCT. Twenty-seven percent of patients had a poor performance score at transplantation. Ninety-four percent received busulfan and cyclophosphamide-containing conditioning regimens and bone marrow was the predominant source of donor cells. Most patients achieved haematopoietic recovery and no deaths occurred during the early post-transplant period. Rates of acute and chronic graft-versus-host disease were 10% and 22% respectively. Sixty-four of 67 patients are alive with 5-year probabilities of disease-free and overall survival of 85% and 97% respectively. Nine patients had graft failure with recovery of sickle erythropoiesis, eight of who had recurrent sickle-related events. This report confirms and extends earlier reports that HCT from HLA-matched related donors offers a very high survival rate, with few transplant-related complications and the elimination of sickle-related complications in the majority of patients who undergo this therapy.

Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Publishing Authors By Initials

JA Panepinto,MC Walters,J Carreras,J Marsh,CN Bredeson,RP Gale,GA Hale,J Horan,JM Hows,JP Klein,R Pasquini,I Roberts,K Sullivan,M Eapen,A Ferster, ,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: British journal of haematology

VOLUME: 137

Page Numbers: 479-85

Journal Abbreviation: Br. J. Haematol.

ISSN: 0007-1048

DAY: 24

MONTH: 04

YEAR: 2007

Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Information

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LANGUAGE: eng

NlmUniqueID: 372544

Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: immunology

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Grant and Affiliation Information for Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research.

AFFILIATION: Department of Hematology/Oncology/Bone Marrow Transplant, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. jpanepin@mcw.edu

Country: England

AGENCY: United States NCI

GRANT: U24 CA 76518

ACRONYM: CA

MEDLINETA: Br J Haematol

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