Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering.

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Abstract Text:

Kazunori Nishizaki,Hidetsugu Tsujigiwa,Yasushi Takeda,Tadashi Yoshino,Manabu Maeta,Kunihiro Fukushima,Hitoshi Nagatsuka,Noriyuki Nagai,

PURPOSE: Several materials have been used in the application of mastoid cavity obliteration during surgery for cholesteatoma; however, nothing has won universal acceptance. Through the advancement of tissue engineering, bone morphogenetic protein-2 (BMP-2)/collagen composites have been elucidated as inducers of heterogenic bone formation. This study was performed to investigate whether these composites are potentially obliteration materials for use in the mastoid cavity by using an animal experimental study. MATERIALS AND METHODS: The composites were implanted in the rat mastoid to investigate whether new bone would be tissue engineered in the mastoid and, if so, whether the newly formed bone was stable. The composites were examined histologically over a 24-week period. RESULTS: The composites implanted in the rat mastoid were able to tissue engineer new bone, and the newly formed bone was stable as assessed histologically, with almost normal bone structure, that was not resorbed during the 24-week period. Adverse immunological reactions were not found during our observation. CONCLUSIONS: Bone that was tissue engineered by the BMP-2/collagen composites was stable as assessed by histological examination and persisted in the rat mastoid. The present study shows that the composites have the potential to become real materials for use in mastoid obliteration.

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Publishing Authors By Initials

K Nishizaki,H Tsujigiwa,Y Takeda,T Yoshino,M Maeta,K Fukushima,H Nagatsuka,N Nagai,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE: 2003 Jan-Feb

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of otolaryngology

VOLUME: 24

Page Numbers: 14-8

Journal Abbreviation: Am J Otolaryngol

ISSN: 0196-0709

DAY: 19

MONTH: 11

YEAR: 2007

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8000029

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: methods

Chemical & Substance for Abstract: Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering.

AFFILIATION: Departments of Otolaryngology-Head and Neck Surgery, Okayama University Graduate Schools, Okayama, Japan. nishizak@cc.okayama-u.ac.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Otolaryngol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering Related Publications

• A pigmented calcifying cystic odontogenic tumor associated with compound odontoma: a case report and review of literature.
• Amiodarone and N-desethylamiodarone enhance endothelial nitric oxide production in human endothelial cells.
• Annual abdominal ultrasonographic examination after curative NSCLC resection.
• Capacity analysis for a two-level decoupled Hamming network for associative memory under a noisy environment.
• Characterization of PsTX-60B, a new membrane-attack complex/perforin (MACPF) family toxin, from the venomous sea anemone Phyllodiscus semoni.
• Cloning and characterization of rat casein kinase 1epsilon.
• Development of bovine in vitro-matured follicular oocytes activated with ethanol.
• Effects of central injection of l-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats.
• Full-term development of in vitro-matured, vitrified and fertilized bovine oocytes.
• High-throughput solid-phase extraction of metal ions using an iminodiacetate chelating porous disk prepared by graft polymerization.
• Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H(2)(18)O.
• Immobilized rhBMP-2/succinylated type I atelocollagen gene expression of intracellular signaling molecules on ST2 cells.
• Immunolocalization of cell signaling molecules in the granular cell ameloblastoma.
• Inhibitory effect of palatinose on glucose absorption in everted rat gut.
• Isolation and characterization of a novel protein toxin from fire coral.
• Lactobacillus Acidophilus strain L-92 regulates the production of Th1 cytokine as well as Th2 cytokines.
• Mastoid obliteration by BMP-2/collagen composites: an experimental study using tissue engineering.
• Minimum leakage rate (0.5%) of stapled esophagojejunostomy with sacrifice of a small part of the jejunum after total gastrectomy in 390 consecutive patients.
• Morbidity prevalence rate of kawasaki disease assessed by single cross-sectional history-taking.
• Natural course of lower urinary tract symptoms following discontinuation of alpha-1-adrenergic blockers in patients with benign prostatic hyperplasia.
• Nutritional status and risk of amyotrophic lateral sclerosis in Japan.
• Preparation and characterization of platinum-ruthenium bimetallic nanoparticles using reverse microemulsions for fuel cell catalyst.
• Production of platelet-activating factor during focal cerebral ischemia and reperfusion in the rat.
• Salvage esophagectomy following definitive chemoradiotherapy.
• Solid tumor resection by use of a highly sensitive micromagnetic needle detection system.
• Subjective effect of magnetic resonance-guided focused ultrasound surgery for uterine fibroids.
• Thrombomodulin is a clock-controlled gene in vascular endothelial cells.
• [A case of loxoprofen sodium-induced eosinophilic pneumonia that occurred ipsilaterally after VATS lobectomy for lung cancer]
• [Cardiac gene therapy]
• [Trends in molecular targeting therapeutics for chronic myeloid leukemia]