Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo.

Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Research Abstract Details 

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Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Abstract Text:

Toshinao Oyama,Kenichi Harigaya,Ablimit Muradil,Katsuto Hozumi,Sonoko Habu,Hideyuki Oguro,Atsushi Iwama,Kenji Matsuno,Reiko Sakamoto,Mitsuharu Sato,Nobuaki Yoshida,Motoo Kitagawa,Toshinao Oyama,Kenichi Harigaya,Ablimit Muradil,Katsuto Hozumi,Sonoko Habu,Hideyuki Oguro,Atsushi Iwama,Kenji Matsuno,Reiko Sakamoto,Mitsuharu Sato,Nobuaki Yoshida,Motoo Kitagawa,

Mastermind (Mam) is one of the elements of Notch signaling, an ancient system that plays a pivotal role in metazoan development. Genetic analyses in Drosophila and Caenorhabditis elegans have shown Mam to be an essential positive regulator of this signaling pathway in these species. Mam proteins bind to and stabilize the DNA-binding complex of the intracellular domains of Notch and CBF-1, Su(H), Lag-1 (CSL) DNA-binding proteins in the nucleus. Mammals have three Mam proteins, which show remarkable similarities in their functions while having an unusual structural diversity. There have also been recent indications that Mam-1 functionally interacts with other transcription factors including p53 tumor suppressor. We herein describe that Mam-1 deficiency in mice abolishes the development of splenic marginal zone B cells, a subset strictly dependent on Notch2, a CSL protein and Delta1 ligand. Mam-1 deficiency also causes a partially impaired development of early thymocytes, while not affecting the generation of definitive hematopoiesis, processes that are dependent on Notch1. We also demonstrate the transcriptional activation of a target promoter by constitutively active forms of Notch to decrease severalfold in cultured Mam-1-deficient cells. These results indicate that Mam-1 is thus required to some extent for Notch-dependent stages in lymphopoiesis, thus supporting the notion that Mam is an essential component of the canonical Notch pathway in mammals.

Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Publishing Authors By Initials

T Oyama,K Harigaya,A Muradil,K Hozumi,S Habu,H Oguro,A Iwama,K Matsuno,R Sakamoto,M Sato,N Yoshida,M Kitagawa,T Oyama,K Harigaya,A Muradil,K Hozumi,S Habu,H Oguro,A Iwama,K Matsuno,R Sakamoto,M Sato,N Yoshida,M Kitagawa,

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Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 9764-9

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 29

MONTH: 05

YEAR: 2007

Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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AFFILIATION: Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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