Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis.

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Abstract Text:

Erqiu Li,Aiping Zhao,Terez Shea-Donohue,Steven M Singer,

Giardia intestinalis is a significant cause of diarrheal disease worldwide. Infections in animal models have been shown to cause changes in gastrointestinal transit that depend on adaptive immune responses and are mediated, in part, through neuronal nitric oxide synthase. Nitric oxide is an inhibitory neurotransmitter, and we therefore investigated potential excitatory pathways that might be involved in the response to Giardia infection. Infected mice exhibited increased spontaneous and cholecystokinin (CCK)-induced contractions of longitudinal smooth muscle. In contrast, enhanced contractile responses were not observed in response to acetylcholine, 5-hydroxytryptamine, or the protease-activated receptor-1 agonist peptide TFFLR. Giardia-induced changes in smooth muscle function appear to be mediated primarily by mast cells, as both spontaneous and CCK-induced contractions were blocked by pretreatment with either ketotifen or compound 48/80. Together, these data support a model in which CCK release triggers mast cell degranulation, leading to increases in smooth muscle contractility. These contractions, coupled with nitric oxide-mediated muscle relaxation, promote intestinal transit and parasite elimination.

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Publishing Authors By Initials

E Li,A Zhao,T Shea-Donohue,SM Singer,

For similar musculoskeletal system: muscles: muscle, smooth research abstracts see: musculoskeletal system: muscles: muscle, smooth research

PUBMED ID PMID:

MEDLINE DATE:

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 4514-8

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 9

MONTH: 07

YEAR: 2007

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Keywords Mesh Terms:

KEYWORDS: Muscle, Smooth

MESH TERMS: physiology

Chemical & Substance for Abstract: Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis.

AFFILIATION: Department of Biology, Reiss Building, Room 406, Georgetown University, Washington, DC 20057, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI045965

ACRONYM: AI

MEDLINETA: Infect Immun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis Related Publications

• A longitudinal case study of a child with mosaic trisomy 22: language, cognitive, behavioral, physical, and dental outcomes.
• A progressive, fatal dystonia-Parkinsonism syndrome in a patient with primary immunodeficiency receiving chronic IVIG therapy.
• A recipe for randomness.
• Aggressive drug marketing tactics trigger backlash.
• Bupropion for smokers hospitalized with acute cardiovascular disease.
• Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma.
• Combinations of biomarkers predictive of later life mortality.
• Constitutive turnover of cyclin E by Cul3 maintains quiescence.
• Detection and Classification of Movements in Bed using Load Cells.
• Education correction using years in school or reading grade-level equivalent? Comparing the accuracy of two methods in diagnosing HIV-associated neurocognitive impairment.
• Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis.
• In vivo dynamics of RNA polymerase II transcription.
• Laryngeal dystonia as a presenting symptom of young-onset Parkinson's disease.
• Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis.
• Metastasis to the submandibular gland in head and neck carcinomas.
• Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association.
• Postdischarge treatment costs following closure of a state geropsychiatric ward: comparison of 2 levels of community care.
• Prenatal cocaine and tobacco effects on children's language trajectories.
• Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models?
• Selective effects of cyclosporin A on colony-forming lymphoid and myeloid cells in man.
• Sleep and sleep disturbance: from genes to dreams.
• The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.
• The aging experience of well elderly women: initial results.
• The headache doctor: the dog ate my pills and other tales of woe.
• The validity of the 2004 U.S. News & World Report's rankings of schools of social work: a response.
• Tic disorders: neural circuits, neurochemistry, and neuroimmunology.
• Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice.
• Within-trial contrast: pigeons prefer conditioned reinforcers that follow a relatively more rather than a less aversive event.
• [Ectopic prostatic tissue in the uterine cervix]
• [Meningothelial meningioma in a mature cystic teratoma of the ovary]