Massive intoxication involving unusual high concentration of amitriptyline.

Massive intoxication involving unusual high concentration of amitriptyline. Research Abstract Details 

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Massive intoxication involving unusual high concentration of amitriptyline. Abstract Text:

Margalho, Barroso,Eugenia Gallardo,Paula Monsanto,Duarte Nuno Vieira,

Amitriptyline is a tricyclic antidepressant widely used in the treatment of depression. Antidepressant drugs are among the most commonly encountered causes of self-poisoning, as illustrated by several published cases in the literature. This investigation reports a case of massive amitriptyline intoxication, involving a 44-year old female found dead in bed. The presence of this tricyclic antidepressant was revealed by a routine screening procedure. The concentration was calculated by gas chromatography/ electron ionization-mass spectrometry in the selected ion monitoring mode after solid-phase extraction using proadifen as internal standard and was in the post-mortem whole blood sample 85.9 mug/mL. This value was much higher than the reported toxic values ever found in the literature, and may therefore have caused the victim's death. Nortriptyline was also detected in the toxic concentration range, as well as therapeutic levels of diazepam and nor-diazepam. Taking into account both the available circumstantial information and toxicological results, it is very likely that death was caused by self-poisoning. Human & Experimental Toxicology (2007) 26, 667-670.

Massive intoxication involving unusual high concentration of amitriptyline. Publishing Authors By Initials

C Margalho,M Barroso,E Gallardo,P Monsanto,DN Vieira,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: self-injurious behavior: suicide research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: self-injurious behavior: suicide research

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Massive intoxication involving unusual high concentration of amitriptyline. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human & experimental toxicology

VOLUME: 26

Page Numbers: 667-70

Journal Abbreviation:

ISSN: 0960-3271

DAY: 20

MONTH: Aug

YEAR: 2007

Massive intoxication involving unusual high concentration of amitriptyline. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9004560

Massive intoxication involving unusual high concentration of amitriptyline. Keywords Mesh Terms:

KEYWORDS: Suicide

MESH TERMS: blood

Chemical & Substance for Abstract: Massive intoxication involving unusual high concentration of amitriptyline. Information

Substance Name: Nortriptyline

Registry Number: 72-69-5

Grant and Affiliation Information for Massive intoxication involving unusual high concentration of amitriptyline.

AFFILIATION: Instituto Nacional de Medicina Legal, Delegação de Coimbra, Largo da Sé Nova, 3000-213 Coimbra, Portugal. claudiamargalho@iol.pt

Country: England

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MEDLINETA: Hum Exp Toxicol

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