Massive digitoxin intoxication treated with digoxin-specific antibodies in a child.

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Research Abstract Details 

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Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Abstract Text:

K Schmitt,G Tulzer,F Häckel,R Sommer,W Tulzer,

A 20-month-old girl with massive digitoxin intoxication (initial digitoxin serum level: 629 ng/ml) was successfully treated with digoxin-specific antibody fragments (Fab). She presented with moderate signs of digitalis toxicity (somnolence, bradycardia, first-degree AV block) and improved rapidly during fractional Fab administration. Free serum-digitoxin disappeared after 6 vials of Fab (480 mg), but was measurable again on days 6 and 7. This case demonstrated that digoxin-specific antibodies, despite a 30-100 times lesser affinity for digitoxin, are effective in massive digitoxin intoxications. A rebound phenomenon may occur several days later and should be taken into consideration.

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Publishing Authors By Initials

K Schmitt,G Tulzer,F Häckel,R Sommer,W Tulzer,

For similar disorders of environmental origin: poisoning: overdose research abstracts see: disorders of environmental origin: poisoning: overdose research

PUBMED ID PMID:

MEDLINE DATE: 1994 Jan-Feb

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric cardiology

VOLUME: 15

Page Numbers: 48-9

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Keywords Mesh Terms:

KEYWORDS: Overdose

MESH TERMS: therapy

Chemical & Substance for Abstract: Massive digitoxin intoxication treated with digoxin-specific antibodies in a child. Information

Substance Name: Digitoxin

Registry Number: 71-63-6

Grant and Affiliation Information for Massive digitoxin intoxication treated with digoxin-specific antibodies in a child.

AFFILIATION: Children's Hospital of Linz, Austria.

Country: UNITED STATES

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MEDLINETA: Pediatr Cardiol

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