Mass spectrometric imaging of the nervous system.

Mass spectrometric imaging of the nervous system. Research Abstract Details 

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Mass spectrometric imaging of the nervous system. Abstract Text:

S S Rubakhin,N G Hatcher,E B Monroe,M L Heien,J V Sweedler,S S Rubakhin,N G Hatcher,E B Monroe,M L Heien,J V Sweedler,

Mass spectrometric imaging (MSI) integrates multiple fields of analytical and biomedical research with the goal of generating chemical maps that present the identity and location of the elements, molecules, and molecular complexes that comprise biological structures. Rapid advances in the development of MSI, which include a broad range of sampling and mass spectrometry strategies, allow the increasingly information-rich creation of chemical images of structurally complex tissues, individual cells, and even single chromosomes. Here we describe a variety of MSI techniques available to investigate the nervous system, with particular focus on the capability of MSI to examine both normal and diseased brain function. An important investigative tool, MSI offers tremendous potential in fundamental studies of brain chemistry, localization of pharmaceutical compounds, and the discovery of biomarkers for different neuropathologies.

Mass spectrometric imaging of the nervous system. Publishing Authors By Initials

SS Rubakhin,NG Hatcher,EB Monroe,ML Heien,JV Sweedler,SS Rubakhin,NG Hatcher,EB Monroe,ML Heien,JV Sweedler,

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Mass spectrometric imaging of the nervous system. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Current pharmaceutical design

VOLUME: 13

Page Numbers: 3325-34

Journal Abbreviation: Curr. Pharm. Des.

ISSN: 1873-4286

DAY: 29

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 9602487

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AFFILIATION: Department of Chemistry and the Beckman Institute, University of Illinois, Urbana, Illinois 61801, USA.

Country: Netherlands

AGENCY: United States NIDA

GRANT: DA 018310

ACRONYM: DA

MEDLINETA: Curr Pharm Des

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