Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal.

Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Research Abstract Details 

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Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Abstract Text:

Xiaochun Zhu,Lawrence M Sayre,

Substantial work has been carried out to elucidate the nature of protein modification by 4-hydroxy-2-nonenal (HNE) and its relatives. Its keto cousin, 4-oxo-2-nonenal (ONE), which arises from linoleic acid oxidation independently of HNE, was previously reported to form Michael adducts with His and Cys that can subsequently, in part, condense with Lys residues to give imidazolylpyrrole cross-links. Despite mass spectrometric evidence also for ONE-Lys Michael adducts, the latter do not accumulate in solution. A long-lived adduct that has the same mass as the ONE Lys Michael adduct is suggested instead to be the isomeric 4-ketoamide that arises, along with other adducts, from the reversibly-formed ONE Lys Schiff base. The Lys-ketoamide and His-Lys imidazolylpyrrole cross-links appear to be unusually prominent markers of stable protein modification by ONE.

Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Publishing Authors By Initials

X Zhu,LM Sayre,

For similar organic chemicals: imines: schiff bases research abstracts see: organic chemicals: imines: schiff bases research

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MEDLINE DATE:

Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Redox report : communications in free radical rese

VOLUME: 12

Page Numbers: 45-9

Journal Abbreviation: Redox Rep.

ISSN: 1743-2928

DAY: 3

MONTH: 12

YEAR: 2007

Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9511366

Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Keywords Mesh Terms:

KEYWORDS: Schiff Bases

MESH TERMS: chemistry

Chemical & Substance for Abstract: Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Information

Substance Name: 4-hydroxy-2-nonenal

Registry Number: 29343-52-0

Grant and Affiliation Information for Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal.

AFFILIATION: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL53315

ACRONYM: HL

MEDLINETA: Redox Rep

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