Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin.

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Abstract Text:

Masahiro Tachi,Masao Iwamori,

Mass spectrometry (MS) with chemical ionization was found to be a useful tool for characterizing epidermal cholesterol esters (CE) and wax esters (WE), and was applied to analyse them in the epidermis of fetal, adult and keloidal human skin. Increases in the concentrations of CE and WE had occurred by 20 weeks of gestation in association with increasing concentrations of ceramides and cholesterol sulphate. Although adult epidermis contained them in similar concentrations at 25-28 weeks of gestation (13-14% of the total less polar lipids), the molecular species were shown to differ between fetal and adult epidermis by MS. Cholesterol oleate comprised 45% of the total molecular species in adult CE, whereas saturated fatty acids with chain lengths of 15-19 were abundant in fetal CE. Also, unsaturated and shorter chain WE were abundant in adult epidermis in comparison with that in the fetal epidermis, the total chain lengths of fetal and adult WE being 34-42 with a mean chain length of 38.6, and 27-41 with a mean chain length of 34.0, respectively, and the unsaturated molecules in fetal and adult WE amounting to 29% and 45%, respectively. Also, CE and WE in the epidermis of keloidal skin were reduced to 67% and 20% of the levels in normal skin, respectively. Thus, epidermal CE and WE were shown to carry eligible structures for construction of the hydrophobic barrier at the skin and amniotic fluid interface as well as that at the skin and air interface.

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Publishing Authors By Initials

M Tachi,M Iwamori,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental dermatology

VOLUME: 17

Page Numbers: 318-23

Journal Abbreviation: Exp. Dermatol.

ISSN: 1600-0625

DAY: 2

MONTH: 11

YEAR: 2007

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9301549

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin.

AFFILIATION: Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Tohoku University, Miyagi, Japan.

Country: Denmark

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Exp Dermatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin Related Publications

• Alteration in the reactivity of sphingomyelin in mitogen-stimulated lymphocytes.
• Change in the concentration of neutrophil elastase in bronchoalveolar lavage fluid during anesthesia and its inhibition by cholesterol sulfate.
• Changes in the amounts of myelin lipids and molecular species of plasmalogen PE in the brain of an autopsy case with d-bifunctional protein deficiency.
• Developmental changes of neutral glycosphingolipids as receptors for pulmonary surfactant protein SP-A in the alveolar epithelium of murine lung.
• Gel chromatographic characterization of proteins in mucous and serous middle ear effusions of patients with otitis media in comparison to serum proteins.
• Inhibition of pancreatic elastase by sulfated lipids in the intestinal mucosa.
• Mass spectrometric characterization of cholesterol esters and wax esters in epidermis of fetal, adult and keloidal human skin.
• Occurrence of ceramide phosphorylethanolamine containing hydroxy fatty acid in a bivalve.
• Pseudopregnancy-dependent accumulation of cholesterol sulfate due to up-regulation of cholesterol sulfotransferase and concurrent down-regulation of cholesterol sulfate sulfatase in the uterine endometria of rabbits.
• [Report on nursing management. A study on manpower development in nursing]
• [Transfection of alpha1, 2-fucosyltransferase gene increases the antigenic expression of Lewis y in ovarian cancer cell line RMG-I]