Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces.

Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. Research Abstract Details 

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Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. Abstract Text:

Glenroy D A Martin,Lik T Tan,Paul R Jensen,Rosalba Encarnacion Dimayuga,Craig R Fairchild,Carmen Raventos-Suarez,William Fenical,

Two new cytotoxic quinones of the angucycline class, marmycins A and B ( 1, 2), were isolated from the culture broth of a marine sediment-derived actinomycete related to the genus Streptomyces. The gross structures and absolute configurations of both compounds were determined by spectroscopic and crystallographic methods. Marmycin A ( 1) displayed significant cytotoxicity against several cancer cell lines, some at nanomolar concentrations; while compound 2, a chloro analogue of 1, was less potent. For marmycin A ( 1), tumor cell cytotoxicity appeared to coincide with induction of modest apoptosis and arrest in the G1 phase of the cell cycle.

Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. Publishing Authors By Initials

GD Martin,LT Tan,PR Jensen,RE Dimayuga,CR Fairchild,C Raventos-Suarez,W Fenical,

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Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of natural products

VOLUME: 70

Page Numbers: 1406-9

Journal Abbreviation: J. Nat. Prod.

ISSN: 0163-3864

DAY: 11

MONTH: 09

YEAR: 2007

Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces. Information

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LANGUAGE: eng

NlmUniqueID: 7906882

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Grant and Affiliation Information for Marmycins A and B, cytotoxic pentacyclic C-glycosides from a marine sediment-derived actinomycete related to the genus Streptomyces.

AFFILIATION: Center for Marine Biotechnology, Scripps Insitution of Oceanography, University of California at San Diego, La Jolla, California 92093-0204, USA.

Country: United States

AGENCY: United States NCRR

GRANT: S10RR017768

ACRONYM: RR

MEDLINETA: J Nat Prod

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