Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency.

Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Research Abstract Details 

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Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Abstract Text:

Jessica K Devin,Lewis S Blevins,Denise K Verity,Qingxia Chen,John R Bloodworth,Joseph Covington,Douglas E Vaughan,

CONTEXT: Adults with GH deficiency (GHD) have multiple cardiovascular risk factors, including an unfavorable lipid profile and body composition as well as impairments in endothelial function and cardiac performance. We hypothesized that GHD is associated with elevated levels of plasminogen activator inhibitor-1 (PAI-1), the major inhibitor of plasminogen activation in the circulation. OBJECTIVE: The objective of the study was to determine the fibrinolytic profile of adults with GHD in comparison with controls. STUDY DESIGN AND PARTICIPANTS: This was a prospective, observational study including 12 adults with GHD. Twelve gender-, age-, and body mass index-matched adults served as controls. MAIN OUTCOME MEASURES: The primary outcome measures were circadian plasma PAI-1 antigen with corresponding tissue-plasminogen activator (tPA) activity values. Endothelial function was assessed by flow-mediated vasodilation and fibrinolytic potential by venous occlusion test. RESULTS: Adults with GHD exhibited an unfavorable 24-h fibrinolytic profile characterized by a mean 62% elevation in PAI-1 antigen (2.77 ng/ml after adjustment for baseline PAI-1; P = 0.049) in the setting of a mean 24% reduction in tPA activity (-0.17 IU/ml after adjustment for baseline tPA; P = 0.003). Fibrinolytic response was defective in GHD, as demonstrated by a sustained elevation in PAI-1 activity greater than 4 IU/ml after venous occlusion [7.2 IU/ml (interquartile range 0.8-17.4); P = 0.018]. Endothelial function was impaired in GHD, as quantified by percent flow-mediated vasodilation over 120 sec [area under the curve 3.8 (interquartile range -2.4 to 7.9) vs. 12.8 (interquartile range 2.1-19.4); P = 0.043]. CONCLUSIONS: Adults with GHD demonstrate alterations in plasma fibrinolytic balance, including elevated levels of PAI-1 antigen with decreased tPA activity. These changes may contribute to the increased cardiovascular morbidity within this population.

Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Publishing Authors By Initials

JK Devin,LS Blevins,DK Verity,Q Chen,JR Bloodworth,J Covington,DE Vaughan,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: tissue plasminogen activator research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: tissue plasminogen activator research

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Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 3633-9

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 19

MONTH: 06

YEAR: 2007

Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Keywords Mesh Terms:

KEYWORDS: Tissue Plasminogen Activator

MESH TERMS: metabolism

Chemical & Substance for Abstract: Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency. Information

Substance Name: Tissue Plasminogen Activator

Registry Number: EC 3.4.21.68

Grant and Affiliation Information for Markedly impaired fibrinolytic balance contributes to cardiovascular risk in adults with growth hormone deficiency.

AFFILIATION: Divisions of Endocrinology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. JKS98@Alum.Dartmouth.org

Country: United States

AGENCY: United States NHLBI

GRANT: P50HL081009

ACRONYM: HL

MEDLINETA: J Clin Endocrinol Metab

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ACCESSION NUMBER: NCT00397319

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