Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method.

Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. Research Abstract Details 

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Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. Abstract Text:

Sung-Ryong Ko,Yukio Suzuki,Kei Suzuki,Kang-Ju Choi,Byung-Goo Cho,Sung-Ryong Ko,Yukio Suzuki,Kei Suzuki,Kang-Ju Choi,Byung-Goo Cho,

The hydrolysis of protopanaxadiol-type saponin mixture by various glycoside hydrolases was examined. Among these enzymes, crude preparations of lactase from Aspergillus oryzae, beta-galactosidase from A. oryzae, and cellulase from Trichoderma viride were found to produce ginsenoside F(2) [3-O-(beta-D-glucopyranosyl)-20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol], compound K [20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol], and ginsenoside Rd {3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl]-20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol}, respectively, from protopanaxadiol-type saponin mixture in large quantities. Moreover, the crude preparation of lactase from Penicillium sp. having a high producing activity of ginsenoside Rh(1) (6-O-beta-D-glucopyranosyl-20(S)-protopanaxatriol) from protopanaxatriol-type saponin mixture gave ginsenoside Rd as a main product, ginsenoside Rg(3) {3-O-[beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl]-20(S)-protopanaxadiol}, and compound K from protopanaxadiol-type saponin mixture. The hydrolytic pathways of ginsenosides Rb(1), Rb(2), and Rc to ginsenosides Rd, Rg(3), and F(2), and compound K by crude preparations of four glycoside hydrolases were also studied. This is the first report on the enzymatic preparation of an intestinal bacterial metabolite, ginsenoside F(2), in quantity, and a considerable amount of a minor saponin, ginsenoside Rg(3), from a protopanaxadiol-type saponin mixture.

Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. Publishing Authors By Initials

SR Ko,Y Suzuki,K Suzuki,KJ Choi,BG Cho,SR Ko,Y Suzuki,K Suzuki,KJ Choi,BG Cho,

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Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemical & pharmaceutical bulletin

VOLUME: 55

Page Numbers: 1522-7

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 5

MONTH: Oct

YEAR: 2007

Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. Information

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LANGUAGE: eng

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AFFILIATION: K T & G Central Research Institute, Daejeon, Korea. srko@ktng.com

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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