Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution.

Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Research Abstract Details 

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Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Abstract Text:

Fumie Mizushima,Katsuhiko Minoura,Koji Tomoo,Miho Sumida,Taizo Taniguchi,Toshimasa Ishida,Fumie Mizushima,Katsuhiko Minoura,Koji Tomoo,Miho Sumida,Taizo Taniguchi,Toshimasa Ishida,

The heparin-induced self-aggregation behaviours of four repeat peptides (R1-R4) in an acidic solution (pH = 4.5) were investigated by fluorescence and circular dichroism (CD) measurements and compared with those in a neutral solution (pH = 7.5). In contrast with the self-aggregation-resistive behaviours of the R1 and R4 repeat peptides in the neutral solution, the R4 peptide formed a filament similarly to the R2 and R3 peptides in the acidic solution, whereas the R1 peptide still showed resistive behaviour for filament formation. This is the first report on the markedly different self-aggregation behaviours of the first and fourth repeat peptides on tau microtubule-binding domain.

Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Publishing Authors By Initials

F Mizushima,K Minoura,K Tomoo,M Sumida,T Taniguchi,T Ishida,F Mizushima,K Minoura,K Tomoo,M Sumida,T Taniguchi,T Ishida,

For similar microtubule-associated proteins: tau proteins research abstracts see: microtubule-associated proteins: tau proteins research

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Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 142

Page Numbers: 49-54

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 24

MONTH: 04

YEAR: 2007

Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Keywords Mesh Terms:

KEYWORDS: tau Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution. Information

Substance Name: Heparin

Registry Number: 9005-49-6

Grant and Affiliation Information for Marked difference between self-aggregations of first and fourth repeat peptides on tau microtubule-binding domain in acidic solution.

AFFILIATION: Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan.

Country: Japan

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MEDLINETA: J Biochem (Tokyo)

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