MarA-like regulator of multidrug resistance in Yersinia pestis.

MarA-like regulator of multidrug resistance in Yersinia pestis. Research Abstract Details 

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MarA-like regulator of multidrug resistance in Yersinia pestis. Abstract Text:

Rupa A Udani,Stuart B Levy,

MarA47(Yp) from Yersinia pestis, showing 47% identity to Escherichia coli MarA in its N terminus, caused resistance to antibiotics and to organic solvents when expressed in both E. coli and Y. pestis. Resistance was linked to increased expression of the AcrAB multidrug efflux pump. In four of five spontaneous multidrug-resistant mutants of Y. pestis independently selected by growth on tetracycline, the marA47(Yp) gene was overexpressed. The findings suggest that marA47(Yp) is a marA ortholog in Y. pestis.

MarA-like regulator of multidrug resistance in Yersinia pestis. Publishing Authors By Initials

RA Udani,SB Levy,

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MarA-like regulator of multidrug resistance in Yersinia pestis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Antimicrobial agents and chemotherapy

VOLUME: 50

Page Numbers: 2971-5

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ISSN: 0066-4804

DAY: 3

MONTH: Sep

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 315061

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AFFILIATION: Center for Adaptation Genetics and Drug Resistance, Department of Molecular Biology, Tufts University School of Medicine, Boston, MA 02111, USA.

Country: United States

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MEDLINETA: Antimicrob Agents Chemother

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