Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI.

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Abstract Text:

Caterina Mainero,Wei-Ting Zhang,Ashok Kumar,Bruce R Rosen,A Gregory Sorensen,

Following injury and inflammation, pain to light stroking (dynamic mechanical allodynia) might develop at the damaged site (primary area) or in adjacent normal tissue (secondary area). Using fMRI we mapped changes in the spinal trigeminal nucleus (spV), and supraspinal brainstem nuclei following heat/capsaicin-induced primary and secondary dynamic mechanical allodynia in the human trigeminal system. The role of these structures in dynamic mechanical allodynia has not been clarified yet in humans. During the control session we applied the same mechanical stimuli to the same untreated trigeminal area. Primary and secondary mechanical allodynia showed equal levels of perceived pain intensity, and compared to control mechanical stimulation exhibited similar responses in the ipsilateral spV and contralateral ventrolateral periaqueductal gray (vlPAG). Activity in the spV was significantly higher during both conditions versus the control mechanical stimulation, indicating that central sensitization of second-order neurons is similar for primary and secondary mechanical allodynia. The vlPAG showed decreased activity that inversely correlated with pain ratings during primary allodynia, i.e. the more deactivated the vlPAG the higher the pain intensity (p<0.05, Pearson's correlation). Primary and secondary dynamic mechanical allodynia were also characterized by significant differences involving distinct supraspinal structures mainly involved in pain modulation and including the rostroventromedial medulla, pons reticular formation, dorsolateral PAG, all more active during primary versus secondary allodynia, and the medial reticular formation of the caudal medulla that was more active during secondary versus primary allodynia. These results indicate that the pain modulatory system is involved to a different extent during primary versus secondary mechanical allodynia.

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Publishing Authors By Initials

C Mainero,WT Zhang,A Kumar,BR Rosen,AG Sorensen,

For similar nervous system: peripheral nervous system: peripheral nerves: cranial nerves: trigeminal nerve research abstracts see: nervous system: peripheral nervous system: peripheral nerves: cranial nerves: trigeminal nerve research

PUBMED ID PMID:

MEDLINE DATE:

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: NeuroImage

VOLUME: 35

Page Numbers: 1201-10

Journal Abbreviation:

ISSN: 1053-8119

DAY: 4

MONTH: 02

YEAR: 2007

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9215515

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Keywords Mesh Terms:

KEYWORDS: Trigeminal Nerve

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI.

AFFILIATION: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. caterina@nmr.mgh.harvard.edu <caterina@nmr.mgh.harvard.edu>

Country: United States

AGENCY: United States NCRR

GRANT: P41RR014075

ACRONYM: RR

MEDLINETA: Neuroimage

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI Related Publications

• A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System.
• A downloadable three-dimensional virtual model of the visible ear.
• A synthesis of (+)-FR182877, featuring tandem transannular Diels-Alder reactions inspired by a postulated biogenesis.
• A theoretical study of Favorskii reaction stereochemistry. Lessons in torquoselectivity.
• Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI.
• Analysis of milk production traits in early lactation using a reaction norm model with unknown covariates.
• Assertions of "future dangerousness" at federal capital sentencing: rates and correlates of subsequent prison misconduct and violence.
• Assessment and clinical interpretation of polysaccharide antibody responses.
• Capital offenders in Texas prisons: rates, correlates, and an actuarial analysis of violent misconduct.
• Characteristics of participants in a cancer prevention intervention designed for multiethnic workers in small manufacturing worksites.
• Contingency management interventions for HIV-related behaviors.
• Convergent, enantioselective syntheses of guanacastepenes A and E featuring a selective cyclobutane fragmentation.
• Cost-effectiveness of vitamin therapy for age-related macular degeneration.
• Diagnosis and surgical removal of the mandibular impacted third molar.
• Engaging, understanding and including young people in the provision of mental health services.
• Experience with an organ procurement organization-based non-directed living kidney donation programme.
• Mapping the spinal and supraspinal pathways of dynamic mechanical allodynia in the human trigeminal system using cardiac-gated fMRI.
• Methadone maintenance therapy in residential therapeutic community settings: challenges and promise.
• Neutralising antibodies to interferon beta in multiple sclerosis : expert panel report.
• Non malignant gastrointestinal shortcircuit. (Gastrojejunocolic fistula and gastroileostomy).
• OC121: Endometrial polyps, a frequent diagnosis at sonohysterography-do they cause abnormal uterine bleeding?
• Pharmacokinetics of 1,8-cineole, a dietary toxin, in the brushtail possum (Trichosurus vulpecula): significance for feeding.
• Preparation and crystal structure of two bicyclo[1.1.0]butan-2-ones: a hybrid oxyallyl-cyclopropanone motif.
• Primary isolated nodular amyloidosis of the lung.
• Process evaluation results from the Healthy Directions-Small Business study.
• Sample-angle feedback for diffraction anomalous fine-structure spectroscopy.
• Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.
• System analysis and improvement in the process of transplant patient care.
• The Outer membrane protein OmpA of Mannheimia haemolytica A1 is involved in the binding of fibronectin.
• Ventricular-assist devices and total artificial hearts.