Mapping the electrostatic potential within the ribosomal exit tunnel.

Mapping the electrostatic potential within the ribosomal exit tunnel. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Mapping the electrostatic potential within the ribosomal exit tunnel. Abstract Text:

Jianli Lu,William R Kobertz,Carol Deutsch,

Electrostatic potentials influence interactions among proteins and nucleic acids, the orientation of dipoles and quadrupoles, and the distribution of mobile charges. Consequently, electrostatic potentials can modulate macromolecular folding and conformational stability, as well as rates of catalysis and substrate binding. The ribosomal exit tunnel, along with its resident nascent peptide, is no less susceptible to these consequences. Yet, the electrostatics inside the tunnel have never been measured. Here we map both the electrostatic potential and accessibilities along the length of the tunnel and determine the electrostatic consequences of introducing a charged amino acid into the nascent peptide. To do this we developed novel probes and strategies. Our findings provide new insights regarding the dielectric of the tunnel and the dynamics of its local electric fields.

Mapping the electrostatic potential within the ribosomal exit tunnel. Publishing Authors By Initials

J Lu,WR Kobertz,C Deutsch,

For similar cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: organelles: ribosomes research abstracts see: cells: cellular structures: intracellular space: cytoplasm: cytoplasmic structures: organelles: ribosomes research

PUBMED ID PMID:

MEDLINE DATE:

Mapping the electrostatic potential within the ribosomal exit tunnel. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of molecular biology

VOLUME: 371

Page Numbers: 1378-91

Journal Abbreviation: J. Mol. Biol.

ISSN: 0022-2836

DAY: 19

MONTH: 06

YEAR: 2007

Mapping the electrostatic potential within the ribosomal exit tunnel. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985088

Mapping the electrostatic potential within the ribosomal exit tunnel. Keywords Mesh Terms:

KEYWORDS: Ribosomes

MESH TERMS: chemistry

Chemical & Substance for Abstract: Mapping the electrostatic potential within the ribosomal exit tunnel. Information

Substance Name: maleimide

Registry Number: 541-59-3

Grant and Affiliation Information for Mapping the electrostatic potential within the ribosomal exit tunnel.

AFFILIATION: Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104-6085, USA.

Country: England

AGENCY: United States NIGMS

GRANT: R01 GM052302-12

ACRONYM: GM

MEDLINETA: J Mol Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Mapping the electrostatic potential within the ribosomal exit tunnel Related Publications

• 14 cellular automata as microscopic models of cell migration in heterogeneous environments.
• Biogenesis of the T1-S1 linker of voltage-gated K+ channels.
• Biophysical studies of blood plasma proteins; separation and properties of the immune globulins of the sera of hyperimmunized cows.
• Conference Craziness Converges on JNPT.
• Configural processing in face recognition in schizophrenia.
• Cross talk between activation and slow inactivation gates of Shaker potassium channels.
• Delayed symptomatic presentation of epidural hematoma after epidural catheter anesthesia: case report.
• Enhancement of radiation response by inhibition of Aurora-A kinase using siRNA or a selective Aurora kinase inhibitor PHA680632 in p53-deficient cancer cells.
• Generalized Public Health Nursing Service in Cities.
• Immunological studies on egg white proteins; precipitation of chicken-ovalbumin and conalbumin by rabbit- and horse-antisera.
• JNPT Unveils its Strategic Plan.
• JNPT at the World Congress of Physical Therapy.
• John Watson's proposal.
• Key mechanisms of early lung development.
• Knockdown of ribosomal protein S3 protects human cells from genotoxic stress.
• Mapping the electrostatic potential within the ribosomal exit tunnel.
• Phosphorylation and adenine nucleotide uptake of actomyosin and actin-free myosin.
• Probing the cavity of the slow inactivated conformation of shaker potassium channels.
• Quantitative flow cytometry of ZAP-70 levels in chronic lymphocytic leukemia using molecules of equivalent soluble fluorochrome.
• Radiopacity of endodontic materials on film and a digital sensor.
• Sideband cooling while preserving coherences in the nuclear spin state in group-II-like atoms.
• Tertiary and quaternary structure formation of voltage-gated potassium channels.
• The clinical decision-making process of prescribing power mobility for a child with cerebral palsy.
• The physiological relevance of the intestinal microbiota - contributions to human health.
• Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress.
• Xanthine in urine stimulates growth of Leishmania promastigotes in vitro.
• [Epidermal growth factor receptor (EGF) in head-and-neck cancers]
• [Not Available.]
• [Not Available.]
• [Not Available.]