Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6.

Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6. Research Abstract Details 

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Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6. Abstract Text:

Xiao-Yang Sun,Zi-Yan Chen,Yasuhiko Kanou,Yoshiko Takagishi,Yoshitaka Hayashi,Tamio Ohno,Yoshiharu Murata,Sen-Ichi Oda,Xiao-yang Sun,Zi-yan Chen,Yasuhiko Kanou,Yoshiko Takagishi,Yoshitaka Hayashi,Tamio Ohno,Yoshiharu Murata,Sen-ichi Oda,Xiao-yang Sun,Zi-yan Chen,Yasuhiko Kanou,Yoshiko Takagishi,Yoshitaka Hayashi,Tamio Ohno,Yoshiharu Murata,Sen-ichi Oda,

The joggle mouse is a recessive ataxic mutant carrying an unknown mutation in a C3H/He (C3H)-derived chromosomal segment. Taking advantage of the mouse genome database, we selected 127 DNA microsatellite markers showing heterozygosity between C3H and C57BL/6J (B6) and a first round of screening for the joggle mutation was performed on B6-jog/+ partial congenic mice (N4). We identified 4 chromosomal regions in which 13 microsatellite markers show heterozygosity between C3H and B6. Then, we analyzed the genotype of these 4 chromosomal regions in mice that showed the joggle phenotype and mapped the jog locus between markers D6Mit104 (111.4 Mb) and D6Mit336 (125.1 Mb) (an interval of 13.7 Mb) on chromosome 6. By using a partial congenic strain together with the mouse genome database, we successfully mapped the chromosomal localization of the jog locus much more efficiently than by conventional linkage analysis.

Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6. Publishing Authors By Initials

XY Sun,ZY Chen,Y Kanou,Y Takagishi,Y Hayashi,T Ohno,Y Murata,S Oda,XY Sun,ZY Chen,Y Kanou,Y Takagishi,Y Hayashi,T Ohno,Y Murata,S Oda,XY Sun,ZY Chen,Y Kanou,Y Takagishi,Y Hayashi,T Ohno,Y Murata,S Oda,

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Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental animals / Japanese Association for La

VOLUME: 56

Page Numbers: 389-92

Journal Abbreviation: Exp. Anim.

ISSN: 1341-1357

DAY: 13

MONTH: Oct

YEAR: 2007

Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6. Information

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LANGUAGE: eng

NlmUniqueID: 9604830

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Grant and Affiliation Information for Mapping of jog Locus to the Region between D6Mit104 and D6Mit336 on Mouse Chromosome 6.

AFFILIATION: Department of Genetics, Division of Stress Adaptation and Protection, Research Institute of Environmental Medicine, Nagoya University.

Country: Japan

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