Mapping functionally related regions of brain with functional connectivity MR imaging.

Mapping functionally related regions of brain with functional connectivity MR imaging. Research Abstract Details 

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Mapping functionally related regions of brain with functional connectivity MR imaging. Abstract Text:

D Cordes,V M Haughton,K Arfanakis,G J Wendt,P A Turski,C H Moritz,M A Quigley,M E Meyerand,

BACKGROUND AND PURPOSE: In subjects who are performing no prescribed cognitive task, functional connectivity mapped with MR imaging (fcMRI) shows regions with synchronous fluctuations of cerebral blood flow. When specific tasks are performed, functional MR imaging (fMRI) can map locations in which regional cerebral blood flow increases synchronously with the performance of the task. We tested the hypothesis that fcMRI maps, based on the synchrony of low-frequency blood flow fluctuations, identify brain regions that show activation on fMRI maps of sensorimotor, visual, language, and auditory tasks. METHODS: In four volunteers, task-activation fMRI and functional connectivity (resting-state) fcMRI data were acquired. A small region of interest (in an area that showed maximal task activation) was chosen, and the correlation coefficient of the corresponding resting-state signal with the signal of all other voxels in the resting data set was calculated. The correlation coefficient was decomposed into frequency components and its distribution determined for each fcMRI map. The fcMRI maps were compared with the fMRI maps. RESULTS: For each task, fcMRI maps based on one to four seed voxel(s) produced clusters of voxels in regions of eloquent cortex. For each fMRI map a closely corresponding fcMRI map was obtained. The frequencies that predominated in the cross-correlation coefficients for the functionally related regions were below 0.1 Hz. CONCLUSION: Functionally related brain regions can be identified by means of their synchronous slow fluctuations in signal intensity. Such blood flow synchrony can be detected in sensorimotor areas, expressive and receptive language regions, and the visual cortex by fcMRI. Regions identified by the slow synchronous fluctuations are similar to those activated by motor, language, or visual tasks.

Mapping functionally related regions of brain with functional connectivity MR imaging. Publishing Authors By Initials

D Cordes,VM Haughton,K Arfanakis,GJ Wendt,PA Turski,CH Moritz,MA Quigley,ME Meyerand,

For similar psychological phenomena and processes: psychomotor performance research abstracts see: psychological phenomena and processes: psychomotor performance research

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Mapping functionally related regions of brain with functional connectivity MR imaging. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJNR. American journal of neuroradiology

VOLUME: 21

Page Numbers: 1636-44

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ISSN: 0195-6108

DAY: 14

MONTH: Oct

YEAR: 2000

Mapping functionally related regions of brain with functional connectivity MR imaging. Information

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LANGUAGE: eng

NlmUniqueID: 8003708

Mapping functionally related regions of brain with functional connectivity MR imaging. Keywords Mesh Terms:

KEYWORDS: Psychomotor Performance

MESH TERMS: physiology

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Grant and Affiliation Information for Mapping functionally related regions of brain with functional connectivity MR imaging.

AFFILIATION: Department of Medical Physics, University of Wisconsin, Madison, USA.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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