MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation.

MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Research Abstract Details 

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MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Abstract Text:

Masashi Akiyama,Yoichi Minami,Kouji Kuriyama,Shigenobu Shibata,

While peripheral oscillators can be reset by humoral factors such as glucocorticoid hormones, indirect neural communications involving sympathetic and parasympathetic neurons from the suprachiasmatic nucleus to various peripheral tissues suggest that autonomic nerve innervations also function in the resetting and synchronization of peripheral tissues. To study the role of sympathetic adrenergic signaling on clock gene expression, we constructed NIH3T3 cells that stably expressed each of three alpha(1)-adrenergic receptor subtypes (alpha(1A), alpha(1B) and alpha(1D)). We found that noradrenaline transiently induced the expression of mPer1, mPer2, and mE4bp4 1-2 h after alpha(1)-receptor activation. The extent and time course of clock gene mRNA induction by noradrenaline or the alpha(1)-receptor agonist phenylephrine (PE) was similar to that seen by 50% horse serum shock. Clock gene mRNA induction by PE was inhibited by U0126, a MEK inhibitor, suggesting involvement of the mitogen-activated protein kinase signaling pathway. We also found that both mPer1 and mPer2 mRNAs were induced in the mouse liver 60 min after PE injection. These results suggest that although humoral factors are important for entrainment of the peripheral clock, the autonomic nervous system may also be involved in the process.

MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Publishing Authors By Initials

M Akiyama,Y Minami,K Kuriyama,S Shibata,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: FEBS letters

VOLUME: 542

Page Numbers: 109-14

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 8

MONTH: May

YEAR: 2003

MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Information

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LANGUAGE: eng

NlmUniqueID: 155157

MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation. Information

Substance Name: Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for MAP kinase-dependent induction of clock gene expression by alpha 1-adrenergic receptor activation.

AFFILIATION: Department of Pharmacology and Brain Science, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan.

Country: Netherlands

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MEDLINETA: FEBS Lett

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