Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source.

Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source. Research Abstract Details 

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Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source. Abstract Text:

Huanwen Chen,David Touboul,Matthias Conradin Jecklin,Jian Zheng,Mingbiao Luo,Renato Zenobi,Huanwen Chen,David Touboul,Matthias Conradin Jecklin,Jian Zheng,Mingbiao Luo,Renato Zenobi,

A home-made extractive electrospray ionization source is coupled to an linear quadrupole ion trap mass spectrometer to investigate ion/molecule reactions of biopolymers at ambient pressure. Multiply charged biopolymers such as peptides and proteins generated in an electrospray are easily reduced to a low charge state by the atmospheric pressure ion/molecule reactions occurring between the multiply charged ions and a strong basic reagent sprayed in neutral form into the electrospray plume. The charge state of the biopolymer ions can be manipulated by controlling the amount of the basic reagent. The production of biopolymer ions with low charge states results in a substantial improvement of sensitivity and reduced spectral congestion in ESI-MS. This is of importance for biopolymer mixture analysis and could have promising applications in proteomics.

Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source. Publishing Authors By Initials

H Chen,D Touboul,MC Jecklin,J Zheng,M Luo,R Zenobi,H Chen,D Touboul,MC Jecklin,J Zheng,M Luo,R Zenobi,

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Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of mass spectrometry (Chichester,

VOLUME: 13

Page Numbers: 273-9

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ISSN: 1469-0667

DAY: 18

MONTH: 10

YEAR: 2007

Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source. Information

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LANGUAGE: eng

NlmUniqueID: 101124748

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Grant and Affiliation Information for Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source.

AFFILIATION: Applied Chemistry Department, East China Institute of Technology, Fuzhou, China.

Country: England

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MEDLINETA: Eur J Mass Spectrom (Chicheste

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