Manidipine attenuates a progressive renal injury in remnant kidneys of rats.

Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Research Abstract Details 

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Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Abstract Text:

The effects of a calcium antagonist, manidipine, on the outcome of the remnant kidney model of chronic renal failure in rats were studied. After 5/6 nephrectomy (5/6 Nx), rats were assigned to one of the following groups, and fed: Nx without manidipine, group 1; diet with 0.01% manidipine, group 2. A sham 5/6 Nx group was also included as the control. Each diet contained the same calories (3.44 kcal/g) and protein (25% casein). Increased systolic blood pressure seen after 8 weeks postablation was less with manidipine in group 2. Group 2 also had significantly less proteinuria. By 12 weeks postablation, group 1 showed severe parenchymal damage, characteristic of end-stage renal pathology. These changes were prevented by manidipine. The percentage of glomeruli with severe structural damage including sclerosis and/or hyalinosis, arbitrarily defined as glomerular sclerosis index (GSI) was significantly less in group 2 (41 +/- 11%) compared with group 1 (58 +/- 10%). Tubulointerstitial injury (TII) was also less in group 2 (29.1 +/- 9.1%) compared with group 1 (45.1 +/- 10.3%). Sham-Nx control group without manidipine showed normal renal morphology (GSI, 0.2 +/- 0.6, TII, 3.8 +/- 1.0). These results indicate that manidipine attenuates the development of end-stage renal pathology in the remnant kidney model of chronic renal failure in rats. The mechanism(s) remains to be elucidated.

Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Publishing Authors By Initials

For similar animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research abstracts see: animals: animal population groups: animals, inbred strains: rats, inbred strains: rats, inbred f344 research

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MEDLINE DATE:

Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood pressure. Supplement

VOLUME: 3

Page Numbers: 80-4

Journal Abbreviation:

ISSN: 0803-8023

DAY: 26

MONTH: 02

YEAR: 1992

Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9300787

Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Keywords Mesh Terms:

KEYWORDS: Rats, Inbred F344

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Manidipine attenuates a progressive renal injury in remnant kidneys of rats. Information

Substance Name: manidipine

Registry Number: 89226-50-6

Grant and Affiliation Information for Manidipine attenuates a progressive renal injury in remnant kidneys of rats.

AFFILIATION: First Department of Internal Medicine, Hamamatsu University School of Medicine, Japan.

Country: NORWAY

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MEDLINETA: Blood Press Suppl

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